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BioNano Interactions:
The development of a rational basis for investigating and understanding how nanomaterials interact within living systems (cells, tissues, organisms, humans) is a fundamental challenge for scientists. Understanding the mechanisms and spatiotemporal aspects of nanomaterial interactions with living systems will enable us to design new nano-based therapies and diagnostic platforms, as well as ensuring that nanomaterials not intended for human contact can be utilized safely. By combining physical chemical approaches with state of the art biological technologies we are framing and developing quantitative bionanoscience. On-going projects include the development of a kinetic model of nanoparticle uptake by cells; elucidation of the portals and mechanisms of nanoparticle uptake by various cells; development of a human blood-brain barrier co-culture model; and mapping of the spatiotemporal pathways utilised by nanoparticles in cells.
The development of a rational basis for investigating and understanding how nanomaterials interact within living systems (cells, tissues, organisms, humans) is a fundamental challenge for scientists. Understanding the mechanisms and spatiotemporal aspects of nanomaterial interactions with living systems will enable us to design new nano-based therapies and diagnostic platforms, as well as ensuring that nanomaterials not intended for human contact can be utilized safely. By combining physical chemical approaches with state of the art biological technologies we are framing and developing quantitative bionanoscience. On-going projects include the development of a kinetic model of nanoparticle uptake by cells; elucidation of the portals and mechanisms of nanoparticle uptake by various cells; development of a human blood-brain barrier co-culture model; and mapping of the spatiotemporal pathways utilised by nanoparticles in cells.
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crossref(2024)
ACCOUNTS OF CHEMICAL RESEARCHno. 23 (2023): 3369-3378
PNAS Nexusno. 4 (2022): pgac172-pgac172
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