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Our research aims to understand the structure and function of the brain. To do so, we take a comparative approach and engineer molecular, viral, and sequencing technologies to measure neuronal connectivity networks and gene expression at scale in disease models and a wide range of vertebrates. We developed the first barcode sequencing-based approaches to map neuronal connectivity, increasing throughput of single-neuron mapping by orders of magnitude and opening the door to single-cell comparative connectomics. We complement these barcoding approaches by in situ sequencing of barcodes and genes. Leveraging these technologies, we ask questions including: How do new brain regions and connections evolve to support new computations? What are the organizing principles and fundamental circuit motifs of the vertebrate brain? And how do drugs of abuse and neurodevelopmental disorders break these principles? Our work is highly interdisciplinary, residing at the interface of molecular engineering, neuroscience, synthetic and evolutionary biology, genomics, virology, and computational biology.
Our research aims to understand the structure and function of the brain. To do so, we take a comparative approach and engineer molecular, viral, and sequencing technologies to measure neuronal connectivity networks and gene expression at scale in disease models and a wide range of vertebrates. We developed the first barcode sequencing-based approaches to map neuronal connectivity, increasing throughput of single-neuron mapping by orders of magnitude and opening the door to single-cell comparative connectomics. We complement these barcoding approaches by in situ sequencing of barcodes and genes. Leveraging these technologies, we ask questions including: How do new brain regions and connections evolve to support new computations? What are the organizing principles and fundamental circuit motifs of the vertebrate brain? And how do drugs of abuse and neurodevelopmental disorders break these principles? Our work is highly interdisciplinary, residing at the interface of molecular engineering, neuroscience, synthetic and evolutionary biology, genomics, virology, and computational biology.
研究兴趣
论文共 40 篇作者统计合作学者相似作者
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Ashwin De Silva, Rahul Ramesh,Lyle H. Ungar,Marshall G. Hussain Shuler, Noah J. Cowan,Michael Platt, Chen Li,Leyla Isik, Seung-Eon Roh,Adam Charles,Archana Venkataraman,Brian Caffo,
arXiv (Cornell University)pp.347-357, (2023)
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Dylan Z Faltine-Gonzalez,Justus M Kebschull
Joshua T. Vogelstein,Timothy Verstynen,Konrad P. Kording,Leyla Isik,John W. Krakauer,Ralph Etienne-Cummings,Elizabeth L. Ogburn,Carey E. Priebe,Randal Burns, Kwame Kutten,James J. Knierim, James B. Potash,
arxiv(2022)
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Yushu Chen,Xiaoyin Chen, Batuhan Baserdem,Huiqing Zhan,Yan Li, Martin B. Davis,Justus M. Kebschull,Anthony M. Zador,Alexei A. Koulakov,Dinu F. Albeanu
biorxiv(2021)
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