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My laboratory focuses on the analysis of G protein-coupled receptors (GPCRs)—one of the largest protein families found in nature. GPCRs are receptors on the surfaces of cells. A large number of important chemicals in the body—including neurotransmitters, which carry signals from cell to cell, and hormones, which carry signals from one part of the body to another—bind to GPCRs. GPCRs mediate the functions of these critical chemical messengers. Two striking facts illustrate the essential contributions of GPCRs: (1) the entirety of our hereditary information (the human genome) contains approximately 800 distinct GPCR genes, corresponding to 3 to 4 percent of all human genes; (2) 30 to 40 percent of medications act on specific GPCRs.
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MOLECULAR METABOLISM (2024): 101866-101866
Trends in pharmacological sciencesno. 8 (2023): 492-494
HEPATOLOGY (2023): S1999-S1999
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DIABETESno. 12 (2023): 1748-1750
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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