Jurgen Brem - University of Oxford | 人才画像

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Bio

Jurgen Brem currently works at the Department of Chemistry, University of Oxford. Jurgen does research in Medicinal Chemistry, Biochemistry and Catalysis. Their most recent publication is 'SuppInfo_Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis'.

Research Interests

Papers共 171 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

How Clavulanic Acid Inhibits Serine Β-Lactamases

Pauline A. Lang,Mariska de Munnik,Abraham O. Oluwole,Timothy D. W. Claridge,Carol V. Robinson,Jurgen Brem,Christopher J. Schofield

CHEMBIOCHEM（2024）

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Cell-active Small Molecule Inhibitors Validate the SNM1A DNA Repair Nuclease As a Cancer Target

Marcin Bielinski, Lucy R. Henderson,Yuliana Yosaatmadja,Lonnie P. Swift,Hannah T. Baddock, Matthew J. Bowen,Jurgen Brem,Philip S. Jones,Stuart P. Mcelroy,Angus Morrison,Michael Speake, Stan van Boeckel, Els van Doornmalen,Jan van Groningen,Helma van den Hurk,Opher Gileadi,Joseph A. Newman,Peter J. Mchugh,Christopher J. Schofield

Chemical Science (2024)

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Biochemical and Crystallographic Studies of L,d-Transpeptidase 2 from Mycobacterium Tuberculosis with Its Natural Monomer Substrate

Mariska de Munnik,Pauline A. Lang,Karina Calvopina,Patrick Rabe,Juergen Brem,Christopher J. Schofield

COMMUNICATIONS BIOLOGY（2024）

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The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different Β-Lactamase Producers

Zhuoren Ling,Alistair James Macdonald Farley, Aditya Lankapalli, Yanfang Zhang, Shonnette Premchand-Branker, Kate Cook,Andrei Baran,Charlotte Gray-Hammerton,Claudia Orbegozo Rubio,Edgars Suna,Jordan Mathias,Jurgen Brem,Kirsty Sands, Maria Nieto-Rosado, Maria Mykolaivna Trush,Nadira Naznin Rakhi,Willames Martins,Yuqing Zhou,Christopher Joseph Schofield,Timothy Walsh

ENGINEERING (2024): 124-132

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Crystal Structure of the Transpeptidase LdtMt2 from Mycobacterium Tuberculosis in Complex with Acrylamide Analogue 8

M. de Munnik,P.A. Lang,J. Brem, C.J. Schofield

crossref（2023）

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Crystal Structure of the Transpeptidase LdtMt2 from Mycobacterium Tuberculosis in Complex with Alpha-Chloro Ketone 2

M. de Munnik,P.A. Lang,J. Brem, C.J. Schofield

crossref（2023）

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Crystal Structure of the Transpeptidase LdtMt2 from Mycobacterium Tuberculosis in Complex with Maleimide Analogue 4

M. de Munnik,P.A. Lang,J. Brem, C.J. Schofield

crossref（2023）

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Crystal Structure of the Transpeptidase LdtMt2 from Mycobacterium Tuberculosis in Complex with Ebsulfur Analogue 15

M. de Munnik,P.A. Lang,J. Brem, C.J. Schofield

crossref（2023）

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Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183

Andrei Baran,Jevgenijs Kuzmins,Jevgenijs Kuznecovs,Alistair J. M. Farley,Tharindi Panduwawala,Anete Parkova,Pavel A. Donets,Jurgen Brem,Edgars Suna,Christopher J. Schofield,Kirill Shubin

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

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