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个人简介
Our mission is to develop novel mass spectrometry-based proteomics and metabolomics technologies, systems biology approaches, and to apply these tools to biomedical challenges (e.g. Alzheimer’s disease, cancer and immunity). We seek to obtain the full spectra of temporal and spatial omics data at bulk and single-cell-type levels from animal models and human clinical specimens. The multi-omics data include genome, transcriptome, proteome (the whole proteome and modified proteomes such as phosphoproteome and ubiquitinome), metabolome, and interactome. Network analysis and integration of such multi-omics data with phenotypic information offer a systems or holistic view, for unbiased identification of central disease gene/protein/metabolite networks, functional modules and master regulators. Beyond the big data analysis, we develop mouse models for functional and mechanistic studies to validate the derived hypotheses. These studies provide novel insights into the pathogenesis for therapeutic intervention, and may discover disease biomarkers for precision medicine.
研究兴趣
论文共 346 篇作者统计合作学者相似作者
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NATURE CELL BIOLOGY (2024)
Sandi Radko-Juettner,Hong Yue,Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson,Priya Mittal,Zhexin Zhu,Baranda S Hansen,Katherine A Donovan,Moritz Hunkeler,Wojciech Rosikiewicz,Zhiping Wu,
Natureno. 8007 (2024): 442-449
Hao Chen, Yunlin Fu, Mei Han,Xianlin Han,Ling Hao,Tao Huan,Lan Huang,Ming Huang, Qin Ji, Tao Jiang,Yong Jiang,Liang Li,
Sandi Radko-Juettner,Hong Yue,Jacquelyn A. Myers, Raymond D. Carter, Alexis N. Robertson,Priya Mittal,Zhexin Zhu,Baranda S. Hansen,Katherine A. Donovan,Moritz Hunkeler,Wojciech Rosikiewicz,Zhiping Wu,
Naturepp.1-8, (2024)
Jennifer Martinez, R. K. Subbarao Malireddi, Qun Lu,Larissa Dias Cunha, Stephane Pelletier,Sebastien Gingras, Robert Orchard,Jun-Lin Guan, Haiyan Tan,Junmin Peng,Thirumala-Devi Kanneganti, Herbert W. Virgin,
Nature Cell Biologyno. 4 (2024): 1-1
Li Fan,Cheng Tian,Wentao Yang, Xiaoli Liu,Yogesh Dhungana,Haiyan Tan,Evan S Glazer,Jiyang Yu,Junmin Peng,Lichun Ma, Min Ni,Liqin Zhu
biorxiv(2024)
Liam C Hunt, Kudzai Nyamkondiwa,Anna Stephan,Jianqin Jiao,Kanisha Kavdia,Vishwajeeth Pagala,Junmin Peng,Fabio Demontis
bioRxiv : the preprint server for biology (2024)
Carolyn M Jablonowski,Waise Quarni,Shivendra Singh,Haiyan Tan, Dhanushka Hewa Bostanthirige,Hongjian Jin,Jie Fang,Ti-Cheng Chang,David Finkelstein,Ji-Hoon Cho,Dongli Hu,Vishwajeeth Pagala,
Sandi Radko-Juettner,Hong Yue,Jacquelyn A. Myers, Raymond D. Carter, Alexis N. Robertson,Priya Mittal,Zhexin Zhu,Baranda S. Hansen,Katherine A. Donovan,Moritz Hunkeler,Wojciech Rosikiewicz,Zhiping Wu,
Nature (2024)
Sandi Radko-Juettner,Hong Yue,Jacquelyn A. Myers, Raymond D. Carter, Alexis N. Robertson,Priya Mittal,Zhexin Zhu,Baranda S. Hansen,Katherine A. Donovan,Moritz Hunkeler,Wojciech Rosikiewicz,Zhiping Wu,
Naturepp.1-8, (2024)
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