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His research interest lies in discovering and understanding novel receptor-ligand pathways with immune-modulatory functions and how to best utilize them as potential targets for cancer immunotherapy. During these years, Dr. Wang developed several genome-scale proprietary screening platforms leading to valuable industrial partnerships, some of which formed the basis of NextCure, Inc. He has discovered several first-in-class targets, such as FGL1/LAG-3 and Siglec-15, which represent novel tumor immune evasion mechanisms and new approaches for cancer immunotherapy. The first-in-human cancer clinical trials targeting the Siglec-15 pathway are currently ongoing at Yale and NYU, in addition to other sites. Moreover, Dr. Wang also examined the mechanisms of anti-tumor efficacy versus liver toxicity of agonistic anti-CD137 (4-1BB) therapy and provided new insights for alleviating liver pathology without disruption of anti-tumor immunity.Moving forward, Dr. Wang is planning to use innovative technologies to identify key mechanisms within the tumor microenvironment in the control of anti-tumor immunity and to design useful next-generation cancer immunotherapies with rational biomarkers.
研究兴趣
论文共 107 篇作者统计合作学者相似作者
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Tae Kon Kim,Xue Han,Qianni Hu, Esten N. Vandsemb, Carly M. Fielder,Junshik Hong,Kwang Woon Kim,Emily F. Mason, R. Skipper Plowman,Jun Wang,Qi Wang, Jian-Ping Zhang,
JOURNAL OF CLINICAL INVESTIGATIONno. 3 (2024)
Trends in immunologyno. 3 (2024): 177-187
John L Silberstein, Jasper Du, Kun-Wei Chan, Jessica A Frank,Irimpan I Mathews, Yong Bin Kim, Jia You, Qiao Lu,Jia Liu, Elliot A Philips, Phillip Liu, Eric Rao,
Proceedings of the National Academy of Sciences of the United States of Americano. 12 (2024): e2310866121-e2310866121
Elliot A. Philips,Jia Liu,Audun Kvalvaag, Alexander M. Morch, Anna S. Tocheva,Charles Ng, Hong Liang,Ian M. Ahearn,Ruimin Pan,Christina C. Luo, Alexander Leithner, Zhihua Qin,
SCIENCE IMMUNOLOGYno. 93 (2024): eade6256-eade6256
Tae Kon Kim,Xue Han,Qianni Hu, Esten N Vandsemb, Carly M Fielder,Junshik Hong,Kwang Woon Kim,Emily F Mason, R Skipper Plowman,Jun Wang,Qi Wang,Jian-Ping Zhang,
The Journal of clinical investigationno. 3 (2024)
International journal of molecular sciencesno. 11 (2023): 9658-9658
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Xufeng Chen, Li Qiao,Hua Zhou,Jia Liu,Bettina Nadorp,Audrey Lasry,Zhengxi Sun, Jiangyan Zhang, Michael Cammer,Kun Wang, Zoe Ciantra, Jing You,
Blood cancer discoveryno. 3_Supplement (2023): A10-A10
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crossref(2023)
Chunhua Wang,Quan Chen, Meiqing Chen, Sizhen Guo,Ping Hou,Yulian Zou,Jun Wang,Bailin He,Qiuyu Zhang,Lieping Chen,Liqun Luo
CANCER IMMUNOLOGY IMMUNOTHERAPYno. 6 (2023): 1685-1698
crossref(2023)
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