基本信息
浏览量:7
职业迁徙
个人简介
The themes pursued in our laboratory are related to “cancer”, immunity”, and “bones”, since signal transducer TRAF6 and transcription factor NF-κB,which we are interested in, are profoundly involved in tumorigenesis, immune regulation, and bone metabolism. Upon cytokine stimulation, TRAF6 acts as an E3 ubiquitin ligase to generate Lys-63-linked polyubiquitin chains, which do not induce proteasomal degradation, but rather act as platforms for formation of active signal complexes leading to the activation of NF-κB. A number of serious human diseases are caused by various kinds of bone metabolism abnormalities and immunodeficiencies. We were able to reproduce diseases similar to these human diseases in TRAF6- or NF-κB-deficient mice, indicating that TRAF6/NF-κB signals are essential for normal bone formation and the establishment of immunity.
研究兴趣
论文共 317 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Teruya Nakamura, Chiaki Ohyama, Madoka Sakamoto,Tsugumasa Toma,Hiroshi Tateishi, Mihoko Matsuo,Mami Chirifu, Shinji Ikemizu,Hiroshi Morioka,Mikako Fujita,Jun-Ichiro Inoue,Yuriko Yamagata
Proceedings of the National Academy of Sciences of the United States of Americano. 11 (2024): e2318794121-e2318794121
Biomolecules & therapeuticsno. 2 (2024): 262-265
Shu Okugawa,Mahoko Ikeda,Kosuke Kashiwabara,Takashi Moritoyo, Takao Kohsaka, Toshio Shimizu,Hideharu Hagiya,Kou Hasegawa,Fumio Otsuka,Ayumi Miwa,Nobuhito Kisimoto, Ayako Mizoguchi,
International journal of antimicrobial agentsno. 3 (2023): 106922-106922
crossref(2023)
Tadashi Yamamoto,Miho Tokumasu, Atsuko Sato,Taku Ito-Kureha,Mizuki Yamamoto, Nao Ohmine,Kentaro Semba,Jun‐ichiro Inoue
Research Square (Research Square) (2023)
引用0浏览0引用
0
0
crossref(2023)
Omur Guven,Belgin Sever,Faika Basoglu-Unal,Abdulilah Ece,Hiroshi Tateishi,Ryoko Koga,Mohamed O. Radwan, Nefise Demir,Mustafa Can, Mutlu Dilsiz Aytemir,Jun-ichiro Inoue,Masami Otsuka,
PHARMACEUTICALSno. 11 (2023): 1608-1608
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn