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个人简介
The Lieberman laboratory studies cytotoxic T lymphocytes and their role in infection and tumor immunity. They study the molecular pathways used by killer lymphocytes and their cytotoxic granule proteases, called granzymes, and pore-forming proteins, perforin and granulysin, to induce programmed cell death. They have defined a caspase-independent programmed cell death pathway activated by granzyme A. Recent work has identified an unexpected role for granzymes and granulysin in protection against bacteria and parasites. They recently uncovered the molecular basis for inflammatory cell death (pyroptosis) triggered by invasive bacteria and other danger signals and found that it is due to membrane pore formation by an inflammatory caspase-cleaved protein, gasdermin D. This mechanism also directly kills the bacteria that trigger the inflammasome. Current work focuses on innate and adaptive immune responses to invasive pathogens, including bacteria, malaria and other parasites, and fungi, including the role of decidual NK cells in protection against infection in pregnancy.
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论文共 432 篇作者统计合作学者相似作者
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Nature Cancerno. 2 (2024): 218-220
Gang Du, Liam B Healy,Liron David,Caitlin Walker,Tarick J El-Baba,Corinne A Lutomski,Byoungsook Goh, Bowen Gu,Xiong Pi,Pascal Devant,Pietro Fontana,Ying Dong,
Arumugam Balasubramanian,Alan Y Hsu,Laxman Ghimire, Muhammad Tahir,Pascal Devant,Pietro Fontana, Gang Du,Xing Liu,Dang Fabin,Hiroto Kambara,Xuemei Xie, Fei Liu,
Science immunologypp.eadn1452-eadn1452, (2024)
PLoS pathogensno. 1 (2024): e1011923-e1011923
Stefanie Chan, Praveen Sridhar,Rory Kirchner, Ying Jie Lock, Zach Herbert,Silvia Buonamici,Peter Smith,Judy Lieberman,Fabio Petrocca
crossref(2023)
Arumugam Balasubramanian,Laxman Ghimire,Alan Y Hsu,Hiroto Kambara,Xing Liu, Tomoya Hasegawa, Rong Xu, Muhammad Tahir,Hongbo Yu,Judy Lieberman,Hongbo R Luo
biorxiv(2023)
Ken Takashima,Dian-Jang Lee,María Fernanda Trovero,M Hafiz Rothi,Meeta Mistry,Ying Zhang, Zhouyihan Li,Christopher P Davis, Zilan Li, Julia Natale,Ernst Schmid, Joseph Al Haddad,
bioRxiv : the preprint server for biology (2023)
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Dylan V Neel,Himanish Basu,Georgia Gunner, Matthew D Bergstresser,Richard M Giadone,Haeji Chung,Rui Miao,Vicky Chou, Eliza Brody,Xin Jiang,Edward Lee,Michelle E Watts,
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