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The Lieberman laboratory studies cytotoxic T lymphocytes and their role in infection and tumor immunity. They study the molecular pathways used by killer lymphocytes and their cytotoxic granule proteases, called granzymes, and pore-forming proteins, perforin and granulysin, to induce programmed cell death. They have defined a caspase-independent programmed cell death pathway activated by granzyme A. Recent work has identified an unexpected role for granzymes and granulysin in protection against bacteria and parasites. They recently uncovered the molecular basis for inflammatory cell death (pyroptosis) triggered by invasive bacteria and other danger signals and found that it is due to membrane pore formation by an inflammatory caspase-cleaved protein, gasdermin D. This mechanism also directly kills the bacteria that trigger the inflammasome. Current work focuses on innate and adaptive immune responses to invasive pathogens, including bacteria, malaria and other parasites, and fungi, including the role of decidual NK cells in protection against infection in pregnancy.
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Papers共 450 篇Author StatisticsCo-AuthorSimilar Experts
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Current Opinion in Immunology (2024): 102432-102432
Nature Cancerno. 2 (2024): 218-220
SCIENCE IMMUNOLOGYno. 94 (2024): eadn1452-eadn1452
Immunityno. 6 (2024): 1192-1194
PLoS pathogensno. 1 (2024): e1011923-e1011923
Arumugam Balasubramanian,Laxman Ghimire,Alan Y Hsu,Hiroto Kambara,Xing Liu, Tomoya Hasegawa,Rong Xu, Muhammad Tahir,Hongbo Yu,Judy Lieberman,Hongbo R Luo
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Stefanie Chan,Praveen Sridhar,Rory Kirchner, Ying Jie Lock,Zach Herbert,Silvia Buonamici, Peter Smith,Judy Lieberman,Fabio Petrocca
crossref(2023)
Ken Takashima,Dian-Jang Lee,María Fernanda Trovero,M Hafiz Rothi,Meeta Mistry,Ying Zhang, Zhouyihan Li,Christopher P Davis, Zilan Li, Julia Natale,Ernst Schmid,Joseph Al Haddad,
bioRxiv : the preprint server for biology (2023)
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