Juan Carlos Laguna

From initially studying the molecular mechanism of action of hypolipidemic drugs, our interest has expanded to the study of RXR heterodimeric (PPAR, FXR, LXR, etc.) receptors and other nuclear receptors participating in the control of energy metabolism, Further, In the last decade, we have been involved in the study of the metabolic effects, and mechanisms involved, of the sustained consumption of simple sugars. We have studied, by in vivo (Sprague-Dawley rat, LDL-receptor knockout mice) and in vitro approaches (hepatoma cells, primary hepatocyte), the effect of isocaloric supplementation of fructose and glucose solutions on lipid and glucose metabolism for different lengths of time (from two weeks to eleven months) in order to reproduce the full pattern of consumption of these sugar