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Research interests
The research interests of this investigator are within the frame of two major topics: (i) structural characterization of biological macromolecular assemblies, and (ii) nuclear proteins. The first includes both biochemical and biophysical approaches to the study of protein-protein and protein-DNA interactions. Chromatin is the particular biological system presently being analyzed in this area. Current research includes studies on histone-histone interactions, and on histone-DNA interactions at the nucleosome level and at the higher order structure of chromatin. Special attention is being paid to the influence on these interactions of biologically significant chemical modifications, both at the histone and at the DNA level (acetylation, phosphorylation, methylation).
The interest in the second topic comes from the fact that histones are not the only proteins that are associated with DNA inside the cell nucleus. These latter proteins may be, depending on the organism, displaced by a complex broad spectrum of other more basic proteins during the differentiation process of spermatogenesis. These spermatogenic proteins exhibit neither the compositional homogeneity nor the structural features of the typical histones. The current research in this area is centered on the chemistry of such proteins (characterization, sequencing) as well as on the molecular mechanisms involved in the regulation of the genes encoding these proteins.
The research interests of this investigator are within the frame of two major topics: (i) structural characterization of biological macromolecular assemblies, and (ii) nuclear proteins. The first includes both biochemical and biophysical approaches to the study of protein-protein and protein-DNA interactions. Chromatin is the particular biological system presently being analyzed in this area. Current research includes studies on histone-histone interactions, and on histone-DNA interactions at the nucleosome level and at the higher order structure of chromatin. Special attention is being paid to the influence on these interactions of biologically significant chemical modifications, both at the histone and at the DNA level (acetylation, phosphorylation, methylation).
The interest in the second topic comes from the fact that histones are not the only proteins that are associated with DNA inside the cell nucleus. These latter proteins may be, depending on the organism, displaced by a complex broad spectrum of other more basic proteins during the differentiation process of spermatogenesis. These spermatogenic proteins exhibit neither the compositional homogeneity nor the structural features of the typical histones. The current research in this area is centered on the chemistry of such proteins (characterization, sequencing) as well as on the molecular mechanisms involved in the regulation of the genes encoding these proteins.
研究兴趣
论文共 321 篇作者统计合作学者相似作者
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David Ortega-Alarcon,Rafael Claveria-Gimeno,Sonia Vega, Ladan Kalani, Olga C. Jorge-Torres,Manel Esteller,Juan Ausio,Olga Abian,Adrian Velazquez-Campoy
Nucleic acids research (2024)
David Ortega-Alarcon,Rafael Claveria-Gimeno,Sonia Vega, Ladan Kalani, Olga C. Jorge-Torres,Manel Esteller,Juan Ausio,Olga Abian,Adrian Velazquez-Campoy
NUCLEIC ACIDS RESEARCH (2024)
Juan Ausió, Alistair Knox,Bo-Hyun Kim, Elaine Humphrey,Brent Gowen,Naoki Minamino,Patrick von Aderkas
Biochemistry and cell biology = Biochimie et biologie cellulaire (2024)
Melissa R Leyden,Brent Gowen,Rodrigo Gonzalez-Romero,Jose Maria Eirin-Lopez,Bo-Hyun Kim,Fumio Hayashi, Jay McCartney, Patrick C Zhang,Miyoko Kubo-Irie,Jeffrey Shabanowitz,Donald F Hunt,Patrick Michael Ferree,
Biochemistry and cell biology = Biochimie et biologie cellulaire (2024)
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023): S131-S132
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023): S248-S249
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Psychiatric geneticsno. 6 (2023): 213-232
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Jessica Gonzalez,Laia Bosch-Presegue,Anna Marazuela-Duque, Anna Guitart-Solanes,Maria Espinosa-Alcantud,Agustin F. Fernandez,Jeremy P. Brown,Juan Ausio,Berta N. Vazquez,Prim B. Singh, Mario F. Fraga,Alejandro Vaquero
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023): 1293122-1293122
Edilene Siqueira,Bo-Hyun Kim, Larry Reser,Robert Chow,Kerry Delaney,Manel Esteller,Mark M. Ross,Jeffrey Shabanowitz,Donald F. Hunt,Sonia Guil,Juan Ausio
Epigeneticsno. 1 (2023): 2276425
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