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Dr. Asenjo has made important cientific contributions in three main areas:
First in pioneering the development, use and mathematical modeling of enzyme systems for the lysis and permeabilization of microbial cells. His work has elucidated the mechanism of regulation of the synthesis of the enzyme components of lytic systems in two bacteria: Cytophaga and Oerskovia. A pure lytic glucanase has been isolated which is capable of permeabilizing the wall of yeast and hence selectively releasing intra-cellular recombinant proteins (VLPs which are presently being used for an AIDS vaccine) from the yeast cells. His group has been successful in cloning several of the lytic glucanases. In this area he has also made an important contribution in developing mathematical models of the kinetics of biological systems including population balance analysis that have a critical importance due to the non-homogeneity of biological systems.
First in pioneering the development, use and mathematical modeling of enzyme systems for the lysis and permeabilization of microbial cells. His work has elucidated the mechanism of regulation of the synthesis of the enzyme components of lytic systems in two bacteria: Cytophaga and Oerskovia. A pure lytic glucanase has been isolated which is capable of permeabilizing the wall of yeast and hence selectively releasing intra-cellular recombinant proteins (VLPs which are presently being used for an AIDS vaccine) from the yeast cells. His group has been successful in cloning several of the lytic glucanases. In this area he has also made an important contribution in developing mathematical models of the kinetics of biological systems including population balance analysis that have a critical importance due to the non-homogeneity of biological systems.
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Rishi Vachaspathy Astakala,Gagan Preet, Ahlam Haj Hasan, Ria Desai,Juan A. Asenjo,Barbara Andrews,William T. A. Harrison,Rainer Ebel,Marcel Jaspars
Molbankno. 2 (2024)
BIOTECHNOLOGY AND BIOENGINEERING (2024)
BIOTECHNOLOGY AND BIOENGINEERING (2024)
MARINE DRUGSno. 11 (2023): 586-586
Valeria Razmilic,Imen Nouioui,Andrey Karlyshev, Rana Jawad,Martha E. Trujillo, Jose M. Igual,Barbara A. Andrews,Juan A. Asenjo,Lorena Carro,Michael Goodfellow
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGYno. 12 (2023)
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