基本信息
浏览量:4
职业迁徙
个人简介
Our lab aims to achieve a quantitative, comprehensive understanding of cellular metabolism. Our motivation for studying metabolism is two-fold. From a basic science perspective, the molecular connections involved in metabolism are the best understood of any major biochemical network. Accordingly, metabolism provides a unique opportunity for quantitative analysis. From a practical perspective, derangements of metabolism are a major cause of disease, and small molecules that inhibit metabolism are the basis of many important pharmaceuticals. Accordingly, systems-level analysis of metabolism is likely to yield discoveries of medical significance.
A major barrier to understanding metabolism has been lack of appropriate tools. Our lab has developed methods for measuring a wide range of cellular metabolites using state-of-the-art mass spectrometry technology. We have used these tools to discover a novel metabolite involved in the pathogenesis of cancer (Dang et al., 2009). We have innovated approaches to quantitating metabolic fluxes by interpreting isotope-labeling data within a rigorous chemical-kinetic framework.
A major barrier to understanding metabolism has been lack of appropriate tools. Our lab has developed methods for measuring a wide range of cellular metabolites using state-of-the-art mass spectrometry technology. We have used these tools to discover a novel metabolite involved in the pathogenesis of cancer (Dang et al., 2009). We have innovated approaches to quantitating metabolic fluxes by interpreting isotope-labeling data within a rigorous chemical-kinetic framework.
研究兴趣
论文共 520 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Kahealani Uehara,Won Dong Lee,Megan Stefkovich, Dipsikha Biswas,Dominic Santoleri,Anna E Garcia Whitlock, William J Quinn Iii, Talia N Coopersmith,Kate Townsend Creasy,Daniel J Rader,Kei Sakamoto,Joshua D Rabinowitz,
The Journal of clinical investigation (2024)
CELL METABOLISMno. 1 (2024): 103-115.e4
bioRxiv : the preprint server for biology (2024)
NATURE CHEMICAL BIOLOGY (2024)
Edward N. Wilson,Congcong Wang,Michelle S. Swarovski,Kristy A. Zera,Hannah E. Ennerfelt,Qian Wang,Aisling Chaney,Esha Gauba, Javier A. Ramos Benitez,Yann Le Guen,Paras S. Minhas, Maharshi Panchal,
Nature Neurosciencepp.1-13, (2024)
Katrin I Andreasson,Edward N Wilson,Congcong Wang, Matthew Xin,Maharshi Panchal,Joshua D Rabinowitz,Paras S Minhas,Michelle S Swarovski,Javier A Ramos Benitez, Aarooran S Durairaj,Aisling Chaney, Chinyere A Iweka,
biorxiv(2024)
Sarah Cherkaoui,Lifeng Yang,Matthew McBride, Christina S Turn,Wenyun Lu, Caroline Eigenmann,George E Allen,Olesya O Panasenko, Lu Zhang,Annette Vu,Kangning Liu,Yimei Li,
bioRxiv : the preprint server for biology (2024)
Yihui Shen,Hoang V. Dinh,Edward R. Cruz,Zihong Chen,Caroline R. Bartman,Tianxia Xiao,Catherine M. Call, Rolf-Peter Ryseck,Jimmy Pratas,Daniel Weilandt, Heide Baron, Arjuna Subramanian,
Nature Chemical Biologypp.1-10, (2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn