Joshua J. Mcelwee - Department of Biology, University College London

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论文共 71 篇作者统计合作学者相似作者

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TARGETING SELECTIVE TYROSINE KINASE 2 (TYK2) INHIBITORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES

Silvana Leit,Bhaskar Srivastava, Nathan E. Genung,Joshua J. McElwee, Denise Levasseur,Scott D. Edmondson

Medicinal Chemistry Reviews 2023 Medicinal Chemistry Reviewspp.157-185, (2023)

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Discovery and Characterization of Novel Inhibitors of CTP Synthase 1 (CTPS1) for the Treatment of Autoimmune and Inflammatory Disease

Joshua J. McElwee,Neelu Kaila,Samantha Carreiro,Sheetal Kumar,Angela V. Toms,Avinash Phadke, Suzanne Jacques,Justin A. Caravella, Kevin Kreutter,Sebastien Campos,Andreas Verras,Steven K. Albanese, Kevin R. Demarco,Michael A. DiMattia,Eric Lynch,Justin Kollman,Peter Tummino

JOURNAL OF IMMUNOLOGYno. 1 (2023)

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Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279

JOURNAL OF MEDICINAL CHEMISTRYno. 15 (2023): 10473-10496

引用19浏览0WOS引用

317 Characterization of Pharmacokinetics, Pharmacodynamics, Tolerability and Clinical Activity in Phase I Studies of the Novel Allosteric Tyrosine Kinase 2 (TYK2) Inhibitor NDI-034858

E. A. Gangolli,S. Carreiro,J. J. McElwee, N. Dave, A. Lombardi, J. Hanna, V. Hosagrahara, B. Srivastava

JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 8 (2022): S54-S54

引用4浏览0引用

33226 Analysis of Histologic and Molecular Improvement in Moderate-to-severe Psoriasis: Results from a Phase 1b Trial of the Novel Allosteric Tyk2 Inhibitor NTX-973

Joshua J. McElwee,Sandra Garcet,Xuan Li,Inna Cueto,Norma Kunjravia,Darshna Rambhia,Bhaskar Srivastava,James G. Krueger

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY（2022）

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Potent and Selective TYK2-JH1 Inhibitors Highly Efficacious in Rodent Model of Psoriasis

Silvana Leit,Jeremy R. Greenwood,Sayan Mondal,Samantha Carriero,Markus Dahlgren,Geraldine C. Harriman, Joshua J. Kennedy-Smith,Rosana Kapeller, Jon P. Lawson,Donna L. Romero,Angela V. Toms,Mee Shelley,Ronald T. Wester,William Westlin,Joshua J. McElwee,Wenyan Miao,Scott D. Edmondson,Craig E. Masse

Bioorganic & Medicinal Chemistry Letters（2022）

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Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms

medRxiv (Cold Spring Harbor Laboratory) (2022)

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Structural Basis for Isoform-Specific Inhibition of Human CTPS1

Eric M. Lynch,Michael A. DiMattia,Steven Albanese,Gydo C. P. van Zundert,Jesse M. Hansen,Joel D. Quispe,Madison A. Kennedy,Andreas Verras,Kenneth Borrelli,Angela Toms,Neelu Kaila,Kevin D. Kreutter,Joshua J. McElwee,Justin M. Kollman

Proceedings of the National Academy of Sciences（2021）

引用29浏览0WOS引用

Mechanistic Understanding of HPK1 Inhibition on Enhanced Human T Cell Activation and Tumor Immunity in a Syngeneic Model

David Ciccone,Vad Lazari,Ian Linney,Michael Briggs,Samantha Carreiro,Christine Loh,Peter Tummino,Joshua McElwee,Alan Collis,Neelu Kaila

CANCER RESEARCH（2021）

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