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Our laboratory is exploring the mode of action of growth factor receptors and the intracellular signaling pathways that are activated in response to growth factor stimulation. Receptor tyrosine kinases and cytoplasmic protein tyrosine kinases play a critical role in the control of many cellular processes including: cell proliferation, differentiation, metabolism, as well as cell survival and cell migration. Various diseases are caused by dysfunctions in receptor tyrosine kinases or in critical components of signaling pathways that are activated by receptors tyrosine kinases. In addition, various developmental disorders are caused by loss of function mutations in receptor tyrosine kinases. We are using biochemical and genetic approaches as well as X-ray crystallography to determine the mechanism of activation of receptor tyrosine kinases, how they recruit target proteins, and the mode of action of downstream signaling proteins in normal cellular processes and in diseases caused by dysfunctional receptor tyrosine kinases.
Specialized Terms: Growth factor receptors; Intracellular signaling pathways; Protein kinases; Phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; Drug discovery
Our laboratory is exploring the mode of action of growth factor receptors and the intracellular signaling pathways that are activated in response to growth factor stimulation. Receptor tyrosine kinases and cytoplasmic protein tyrosine kinases play a critical role in the control of many cellular processes including: cell proliferation, differentiation, metabolism, as well as cell survival and cell migration. Various diseases are caused by dysfunctions in receptor tyrosine kinases or in critical components of signaling pathways that are activated by receptors tyrosine kinases. In addition, various developmental disorders are caused by loss of function mutations in receptor tyrosine kinases. We are using biochemical and genetic approaches as well as X-ray crystallography to determine the mechanism of activation of receptor tyrosine kinases, how they recruit target proteins, and the mode of action of downstream signaling proteins in normal cellular processes and in diseases caused by dysfunctional receptor tyrosine kinases.
Specialized Terms: Growth factor receptors; Intracellular signaling pathways; Protein kinases; Phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; Drug discovery
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Proceedings of the National Academy of Sciences of the United States of Americano. 17 (2024): e2321898121-e2321898121
Proceedings of the National Academy of Sciences of the United States of Americano. 13 (2023)
GYNECOLOGIC ONCOLOGY (2023): S193-S193
bioRxiv : the preprint server for biology (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 16 (2022)
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