基本信息
浏览量:6
职业迁徙
个人简介
Research Summary
Endothelial cells play central roles in development and maintenance of the vascular system and in the processes of inflammation and metastasis. Interactions with cell adhesion molecules, surrounding matrix, and soluble factors directs endothelial cell responses; yet little is known about these complex interactions and the mechanisms involved in signal transduction. Specifically, we are investigating the roles of homotypic and heterotypic cell adhesion molecules, integrins, junction associated molecules, and extracellular matrix components in modulating vascular development and behavior. We are also investigating neural stem cell-endothelial cell interactions and the roles of T-cell and endothelial cell proteinases and proteinase inhibitors in modulating T-cell transendothelial migration and their roles in initiating and maintaining the inflammatory response in murine models of autoimmune disease and in several tissue culture models. A multi-disciplinary approach is used, which includes the use of knockouts, transgenics, tissue and embryo culture model systems of cell adhesion, migration, and angiogenesis.
Specialized Terms: Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular and neuro-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell–Endothelial cell interactions
研究兴趣
论文共 22 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismno. 7 (2023): 1027-1041
Cellular Signalling (2017): 1-15
The American journal of pathologyno. 1 (2010): 197-207
引用32浏览0引用
32
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn