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Major interests of the laboratory are human immunodeficiency virus entry and pathogenesis. Central to both of these processes are the viral envelope glycoproteins, which mediate the binding and fusion of the virus with the target cell and the cytopathic effects of infection. The laboratory is devoted to understanding how virus entry occurs at the molecular level and how neutralizing antibodies interfere with virus entry. Means of eliciting neutralizing antibodies with broader reactivity are being explored. The mechanisms of viral cytopathic effects and the contribution of these processes to CD4 lymphocyte depletion in vivo are being studied.
Another interest of the laboratory is the species-specific block to HIV-1 that operates after virus entry. A component of cytoplasmic bodies, TRIM5α, blocks HIV-1 in Old World monkey cells. Human TRIM5α also exhibits anti-HIV-1 activity, but this is less potent than the monkey orthologue. The mechanism of action and the role of species-specific and individual variation in TRIM5α in virus resistance are being explored
Another interest of the laboratory is the species-specific block to HIV-1 that operates after virus entry. A component of cytoplasmic bodies, TRIM5α, blocks HIV-1 in Old World monkey cells. Human TRIM5α also exhibits anti-HIV-1 activity, but this is less potent than the monkey orthologue. The mechanism of action and the role of species-specific and individual variation in TRIM5α in virus resistance are being explored
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bioRxiv (Cold Spring Harbor Laboratory)no. 2 (2024): e0159423-e0159423
Journal of virologyno. 9 (2023)
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Sneha Ratnapriya,Karunakar Reddy Pothula,Kim-Marie A Dam,Durgadevi Parthasarathy, Héctor Cervera Benet,Ruth Parsons, Xiao Huang, Salam Sammour,Katarzyna Janowska,Miranda Harris,Shamim Ahmed, Samuel Sacco,
bioRxiv : the preprint server for biology (2023)
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Saumya Anang,Shijian Zhang, Christopher Fritschi,Ta-Jung Chiu,Derek Yang,Amos B. Smith,Navid Madani,Joseph Sodroski
Journal of virologyno. 11 (2023): e0117123-e0117123
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Communications Biologyno. 1 (2023): 1-18
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