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Research Interests
Elucidating the mechanistic basis of T cell dysfunction in human cancer; designing and testing the next generation of genetically-directed CAR T cells as immunotherapy for patients with cancer; epigenetic programming of immune cells; dissecting the signaling/molecular requirements for generation of effective memory and effector T cell responses
Research Summary
Research in the Fraietta laboratory focuses on the generation of innovative immunotherapy strategies involving T cells and their impact on immunity, tumor biology and the tissue/tumor microenvironment in the setting of translatable preclinical studies. We use primary patient samples, in vitro systems and cutting-edge animal models to 1) understand the factors and mechanisms associated with successful adoptive transfer of T cells, with the goal of improving the functions of both endogenous and gene-modified T cells, 2) develop mechanism-based strategies to enhance the survival, expansion and potency of infused T cell products directed against tumors and viral pathogens, and 3) devise methods to modulate the host immune environment to optimally activate T cells.
Elucidating the mechanistic basis of T cell dysfunction in human cancer; designing and testing the next generation of genetically-directed CAR T cells as immunotherapy for patients with cancer; epigenetic programming of immune cells; dissecting the signaling/molecular requirements for generation of effective memory and effector T cell responses
Research Summary
Research in the Fraietta laboratory focuses on the generation of innovative immunotherapy strategies involving T cells and their impact on immunity, tumor biology and the tissue/tumor microenvironment in the setting of translatable preclinical studies. We use primary patient samples, in vitro systems and cutting-edge animal models to 1) understand the factors and mechanisms associated with successful adoptive transfer of T cells, with the goal of improving the functions of both endogenous and gene-modified T cells, 2) develop mechanism-based strategies to enhance the survival, expansion and potency of infused T cell products directed against tumors and viral pathogens, and 3) devise methods to modulate the host immune environment to optimally activate T cells.
研究兴趣
论文共 80 篇作者统计合作学者相似作者
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Julie K. Jadlowsky, Rachel Leskowitz, Stephen McKenna,Jayashree Karar,Yujie Ma, Anlan Dai,Gabriela Plesa,Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong,Wei-Ting Hwang,
Molecular Therapy - Methods & Clinical Developmentno. 1 (2024): 101186-101186
Stephen J. Bagley,Meghan Logun,Joseph A. Fraietta,Xin Wang,Arati S. Desai,Linda J. Bagley,Ali Nabavizadeh,Danuta Jarocha, Rene Martins,Eileen Maloney,Lester Lledo, Carly Stein,
Ashley M Fuller,Hawley C Pruitt, Ying Liu, Valerie M Irizarry-Negron, Hehai Pan, Hoogeun Song,Ann DeVine, Rohan S Katti, Samir Devalaraja,Gabrielle E Ciotti, Michael V Gonzalez,Erik F Williams,
The Journal of clinical investigation (2024)
Nannan Li,Jesse L Rodriguez,Yibo Yin,Meghan T Logun,Shengkun Yu, Kelly A Hicks, VIcky Zhang, Laura Zhang,Chuncheng Xie,Jiabin Wang,Joseph A Fraietta,Zev A. Binder,
biorxiv(2024)
Carl H June,Joseph A Fraietta,Gabriela Plesa,Amy Marshall, Mark H O’Hara,Janos L Tanyi,Elizabeth Hexner,Julie Jadlowsky, Matthew Ferrara,Olivia Farrelly, Adam Runkle,Anne Chew,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Sangya Agarwal,M Angela Aznar, Andrew J Rech,Charly R Good, Shunichiro Kuramitsu,Tong Da,Mercy Gohil, Linhui Chen, Seok-Jae Albert Hong,Pranali Ravikumar,Austin K Rennels, January Salas-Mckee,
Immunityno. 10 (2023): 2388-2407.e9
Andrew R Haas, Ryan J Golden,Leslie A Litzky,Boris Engels,Linlin Zhao,Fangmin Xu, John A Taraszka,Melissa Ramones,Brian Granda,Wan-Jung Chang,Julie Jadlowsky, Kim-Marie Shea,
Carl H June,Joseph A Fraietta,Xiaoling Jin,Saba Ghassemi,Joseph Durgin, Ashwin Sannecy, Nandana Mukherjee, Andre Kelly,Alexander Shestov,Jakub Svoboda,Roddy O’Connor
Journal for ImmunoTherapy of Cancerno. Suppl 2 (2023)
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