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Immune-mediated neurological impairment is the outcome of a rather extensive and coordinated series of events that include peripheral lymphocyte activation, disruption of the blood-brain barrier, cellular infiltration into the brain parenchyma, local inflammation and tissue injury. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules (including free radicals, proteases, vasoactive amines, and excitatory neurotransmitters) induce and regulate numerous critical cell functions that perpetuate inflammation, leading to tissue injury, neuro-degeneration, and neurological deficits. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extend conditioned by the unique amino acid sequences that define allelic variants on each of the participating molecules. Genes, either in their germline configuration and/or as part of complex functional networks, play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy.
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论文共 304 篇作者统计合作学者相似作者
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Colin R Zamecnik,Gavin M Sowa,Ahmed Abdelhak,Ravi Dandekar, Rebecca D Bair,Kristen J Wade, Christopher M Bartley,Kerry Kizer,Danillo G Augusto, Asritha Tubati,Refujia Gomez,Camille Fouassier,
Colin R Zamecnik,Gavin M Sowa,Ahmed Abdelhak,Ravi Dandekar,Rebecca D Bair, Kristen J Wade,Christopher M Bartley,Asritha Tubati,Refujia Gomez,Camille Fouassier,Chloe Gerungan, Jessica Alexander,
medRxiv : the preprint server for health sciences (2023)
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MULTIPLE SCLEROSIS JOURNAL (2023): 575-575
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MULTIPLE SCLEROSIS JOURNAL (2023): 114-114
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Jacqueline Williams,Danillo Augusto,Wesley Marin,Kerry Kizer,Kristen J. Wade,Stacy Caillier,Jorge Oksenberg,Jill A. Hollenbach
HLAno. 4 (2023): 363-364
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MULTIPLE SCLEROSIS JOURNAL (2023): 95-96
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Hannah Silverman,Alan Bostrom,Ann Lazar,Refujia Gomez,Adam Santaniello,Adam Renschen,Meagan Harms, Tiffany Cooper,Robin Lincoln,Shane Poole,Roland Henry,Jorge Oksenberg,
NEUROLOGYno. 17 (2023)
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