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My research is aimed to understand the intricate relations between structure and function for cell-matrix and adhesion proteins. Cells are able to adhere to large matrix assemblies by means of very specific surface proteins. Critical physiological and pathological processes such as immune response or metastasis are dependent on these cell-adhesion events. Cell adhesion proteins are usually glycosylated, transmembrane and multi-domain proteins, and therefore difficult to handle in structure-function studies. As their biological function is often localised in a few key domains that participate in interactions with their ligands, we can approach their study by producing separate domains using recombinant techniques. In collaboration with Martin Humphries we aim to investigate the interaction between cell surface integrins and matrix molecules such as fibronectin. Also, I am interested in the involuntary role played by cell adhesion proteins as gateways for invasive pathogens, such as viruses or bacteria. Learning about the molecular know-how of these pathogens may provide crucial clues for our understanding and control of the mechanisms of cell-adhesion interactions.
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TISSUE ENGINEERING PART Ano. 13-14 (2023)
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FIBROUS PROTEINS: STRUCTURES AND MECHANISMS (2017): 457-490
Cellular and Molecular Life Sciencesno. 15 (2008): 2307-2333
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