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Neuropsychiatric disease is one of the most costly health burdens on modern societies. Pharmaceutical therapies have limited efficacy and drug companies are no longer pursuing research in this field due to the poor prospects for success. A fundamental probelm is that neuropsychiatric disorders often involve very specific associations. For example, post-traumatic stress disorder can involve a single traumatic event. Pharmaceutical treatments lack the specificity to target the representation of specific associations in the brain. Our approach is to treat the brain as a complex computing device. A major goal of our research is the development of brain implants that can interact with the brain in order to treat neuropsychiatric disease. We accomplish this through high-channel count neurophysiological recordings, sophisticated algorithms for decoding neuronal informaiton in real-time and closed-loop control of brain stimulation. In this way, we can develop devices that can detect and disrupt maladaptive associations and behaviors and restore the brain to the healthy state.
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Nature Neuroscienceno. 3 (2024): 403-408
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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