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Inorganic Chemistry and Chemical Biology: Applying structure and spectroscopy to understand and augment the reactivity of metalloenzymes and transition metal clusters
Humans and microorganisms alike utilize O2 to activate hydrocarbons in order to maintain proper cell function and detoxify foreign pollutants. Certain anaerobic bacteria and archaea transduce energy derived from arene- or halocarbon-reduction to support growth. Central to all of these processes are unique metalloenzymes that make use of polynuclear inorganic active sites composed of Earth-abundant transition metal ions. Research in the Rittle group focuses on understanding how these active sites functionalize such recalcitrant organic molecules and developing new strategies in the synthesis of reactive inorganic cluster compounds. Using this knowledge, our long-term goal is to develop powerful and selective synthetic catalysts that utilize multiple transition metal ions and to inspire new therapeutic strategies.
Inorganic Chemistry and Chemical Biology: Applying structure and spectroscopy to understand and augment the reactivity of metalloenzymes and transition metal clusters
Humans and microorganisms alike utilize O2 to activate hydrocarbons in order to maintain proper cell function and detoxify foreign pollutants. Certain anaerobic bacteria and archaea transduce energy derived from arene- or halocarbon-reduction to support growth. Central to all of these processes are unique metalloenzymes that make use of polynuclear inorganic active sites composed of Earth-abundant transition metal ions. Research in the Rittle group focuses on understanding how these active sites functionalize such recalcitrant organic molecules and developing new strategies in the synthesis of reactive inorganic cluster compounds. Using this knowledge, our long-term goal is to develop powerful and selective synthetic catalysts that utilize multiple transition metal ions and to inspire new therapeutic strategies.
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论文共 49 篇作者统计合作学者相似作者
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 3 (2024): 1783-1788
INORGANIC CHEMISTRYno. 43 (2023): 17697-17704
bioRxiv : the preprint server for biology (2023)
biorxiv(2023)
Paul Rathke,Jonathan Rittle
Angewandte Chemie (International ed. in English)no. 43 (2023)
Journal of Coordination Chemistryno. 11-14 (2022): 1-11
semanticscholar(2021)
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