Jon R Sayers

基本信息

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职业迁徙

个人简介

Research interests The group is involved in four main areas: Structure-based drug design to generate new antimicrobial agents Molecular mechanisms involved in protein:DNA interactions Microbial proteases, pathogenesis and the host response Biotechnology for biomedical research and drug development

研究兴趣

论文共 116 篇作者统计合作学者相似作者

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Flap endonuclease Substrate Interactions studied using Dynamic Single-Molecule Atomic Force Microscopy

Vinny Verma, Emma L Brudenell, Sophie Cussons, Janine Phipps, Su Chii Kong,Jon R Sayers,Jamie Kayne Hobbs

biorxiv（2024）

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Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins in Escherichia coli

Emma L Brudenell, Manoj B Pohare,Domen Zafred, Janine Phipps,Hailey R Hornsby, John Darby, Junxiao Dai, Ellen Liggett, Kathleen Cain,Perdita Barran,Thushan I de Silva,Jon R Sayers

The Biochemical journal (2024)

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Characterisation of SARS-CoV-2 Membrane Protein-Specific Antibodies as an Additional Serological Target Following COVID-19 Infections Identified Through a High Content Microscopy-Based Platform

Daniel Michael Williams,Hailey Hornsby,Ola M. Shehata,Rebecca Brown, Marta Gallis,Naomi Meardon,Thomas A.H. Newman,Megan Plowright,Domen Zafred,Amber S.M. Shun-Shion,Anthony J. Hodder, Deepa Bliss,

crossref（2023）

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Establishing SARS-CoV-2 membrane protein-specific antibodies as a valuable serological target via high-content microscopy

Daniel M Williams,Hailey R Hornsby,Ola M Shehata,Rebecca Brown,Marta Gallis,Naomi Meardon,Thomas A H Newman,Megan Plowright,Domen Zafred,Amber S M Shun-Shion,Anthony J Hodder,Deepa Bliss,

iScienceno. 7 (2023): 107056-107056

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Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust

Hayley Colton,David Hodgson,Hailey Hornsby,Rebecca Brown,Joanne Mckenzie,Kirsty L Bradley,Cameron James,Benjamin B Lindsey, Sarah Birch, Louise Marsh, Steven Wood, Martin Bayley,

user-5fe1a78c4c775e6ec07359f9（2022）

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Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust [version 3; peer review: 2 approved]

Martin J. Nicklin,David C. James,Domen Zafred,Jon R. Sayers,Goura Kudesia,Sarah L. Rowland-Jones,Paul J. Collini,Thushan I. de Silva,Thomas C. Darton,Hayley Colton,Hailey Hornsby,David Hodgson,

Wellcome Open Research (2022)

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Antibiotics Limit Adaptation of Drug-Resistant Staphylococcus aureus to Hypoxia

Rebecca C Hull,Rosanna C T Wright,Jon R Sayers,Joshua A F Sutton, Julia Rzaska,Simon J Foster,Michael A Brockhurst,Alison M Condliffe

Antimicrob Agents Chemother（2022）

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A high content microscopy-based platform for detecting antibodies to the nucleocapsid, spike and membrane proteins of SARS-CoV-2

D. M. Williams,H. Hornsby, O. M. Shehata, R. Brown, D. Zafred, A. S. M. Shun-Shion, A. J. Hodder, D. Bliss,A. Metcalfe,J. Edgar,D. E. Gordon,J. R. Sayers,

medRxiv (2021)

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Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms