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Presently, Dr. Mellors' laboratory focuses on resistance to antiretroviral drugs used for treatment and HIV prevention and on mechanisms of HIV persistence and strategies to deplete the reservoirs that are the barrier to curing HIV infection. His work on HIV reservoirs showed that low-level viremia persists in most individuals on long-term suppressive ART, and that the level of residual viremia is predicted by the level of viremia before ART. Current work focuses on identifying agents to reverse HIV latency and to eliminate HIV infected cells. The impact of innovative therapies on HIV reservoirs is being studied in Phase I/II trials of histone deacetylase inhibitors, monoclonal antibodies to immune checkpoint ligands, monoclonal antibodies to HIV envelope glycoproteins, and TLR agonists.
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论文共 446 篇作者统计合作学者相似作者
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Meng Wang,Jennifer Yoon,Hailey Reisert, Bibhuprasad Das, Benjamin Orlinick,Jennifer Chiarella,Elias K Halvas,John Mellors,Alina Ps Pang,Lydia Aoun Barakat, Margaret Fikrig,Joshua Cyktor,
Renee R Anderko, Allison E DePuyt, Rhianna Bronson, Arlene C Bullotta,Evgenia Aga, Ronald J Bosch,R Brad Jones,Joseph J Eron,John W Mellors,Rajesh T Gandhi,Deborah K McMahon,Bernard J Macatangay,
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