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My research interests include the role of biomarkers, especially MRI, SPECT and PET imaging, in the differential and early diagnosis of dementia, including identifying those 'at risk' of future cognitive decline and developing markers of onset and progression of disease.
My other main research interest is in late-life depression, especially the role of vascular and inflammatory factors in precipitating and perpetuating depression in late-life, and the ability of vascular interventions to improve or prevent depressive and cognitive symptoms.
I am also the NIHR Clinical Research Network National Specialty Lead for Dementia and a member of several clinical guideline groups (e.g. NICE 2018).
Our group undertakes a number of multimodal MR, ligand PET and MEG studies, longitudinal clinical and e-record studies, and we also carry out a number of clinical studies in dementia, including trials of pharmacological and non-pharmacological management.
研究兴趣
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Ludmila Kucikova, Hoda Kalabizadeh, Kimberly Gamuchirai Motsi, Sidrah Rashid,John T. O'Brien,John-Paul Taylor,Li Su
AGEING RESEARCH REVIEWS (2024): 102159
Ingrid Buller-Peralta,Sarah Gregory,Audrey Low,Maria-Eleni Dounavi, Katie Bridgeman, Georgios Ntailianis,Brian Lawlor,Lorina Naci,Ivan Koychev,Paresh Malhotra,John T O'Brien,Craig W Ritchie,
Scientific reportsno. 1 (2024): 573-573
Brain communicationsno. 4 (2023)
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Journal of the International Neuropsychological Society : JINSpp.1-7, (2023)
Journal of neurologyno. 10 (2023): 4949-4958
Movement Disordersno. 7 (2023): 1316-1326
Ageing Research Reviews (2023): 101992-101992
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Neurologyno. 12 (2023): e1196-e1205
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