基本信息
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个人简介
Research interest
My lab is interested in how cell death and inflammation are regulated. We focus on three key families of molecules:
The tumor necrosis factor super family (TNFSF) that regulates the immune system and inflammation.
Ubiquitin E3 ligases that play an important role regulating signalling from the TNFSF and other critical immune regulators.
RIP Kinases, which play an important role in effecting inflammation, apoptotic and necroptotic cell death.
My lab uses a wide array of approaches including biochemistry, cell biology, small molecules and genetics so that discoveries made at the molecular level can be transposed into physiological findings in vivo. Using this approach I hope we can make medically relevant discoveries that can be translated into human treatments.
研究兴趣
论文共 341 篇作者统计合作学者相似作者
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Hong Tri Tran,Tobias Kratina, Auriane Coutansais, Dominika Michalek,Benjamin M. Hogan,Kate E. Lawlor,James E. Vince,John Silke,Najoua Lalaoui
Cell Death & Differentiationpp.1-10, (2024)
Nature Reviews Cancerpp.1-17, (2024)
Panxue Wang,John Silke
Nature Cell Biologypp.1-2, (2024)
Nature (2024)
Hirotsugu Oda,Kalpana Manthiram,Pallavi Pimpale Chavan,Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch,Shuichiro Nakabo,Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik,
Nature immunologypp.1-14, (2024)
PNAS NEXUSno. 1 (2023): pgad438-pgad438
Journal of Investigative Dermatologyno. 5 (2023): S260-S260
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The EMBO Journalno. 5 (2023)
Cell death & diseaseno. 7 (2023): 453-15
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