John Yates
教授
Department of Molecular Medicine
The Scripps Research Institute;Yates Laboratory, Department of Chemical Physiology, The Scripps Research Institute;Department of Molecular and Cellular Neuroscience, The Scripps Research Institute;Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute
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基本信息
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Research Focus
Genomic and EST sequencing projects are providing a sequence infrastructure that is changing how protein biochemistry is practiced. These data along with mass spectrometry provide the cornerstone technologies fueling the proteomics revolution. Our group is focused on developing tools and strategies in proteomics to answer basic biological questions. By coupling the additional amino acid sequence information that can be obtained using peptide tandem mass spectrometry to "back-end" database searching and "front-end" separative techniques, we are able to directly analyze extremely complex protein mixtures. The applications for these technologies vary from analyzing purified protein complexes to studying host-pathogen interactions in diseases such as malaria or anthrax. We are further extending these applications to find post-translational modifications to the proteins within these same complex mixtures.
Genomic and EST sequencing projects are providing a sequence infrastructure that is changing how protein biochemistry is practiced. These data along with mass spectrometry provide the cornerstone technologies fueling the proteomics revolution. Our group is focused on developing tools and strategies in proteomics to answer basic biological questions. By coupling the additional amino acid sequence information that can be obtained using peptide tandem mass spectrometry to "back-end" database searching and "front-end" separative techniques, we are able to directly analyze extremely complex protein mixtures. The applications for these technologies vary from analyzing purified protein complexes to studying host-pathogen interactions in diseases such as malaria or anthrax. We are further extending these applications to find post-translational modifications to the proteins within these same complex mixtures.
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论文共 1392 篇作者统计合作学者相似作者
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Raquel de Almeida Schneider,Paula Barros Terraciano, Pamela Zanon, Leticia Quandt, Debora Helena Zanini Gotardi,Tuane Nerissa Alves Garcez,Lucelia Santi, Walter Orlando Beys da Silva,Ivan Sereno Montenegro,John Yates,Jorge Almeida Guimara,Eduardo Pandolfi Passos,
TOXICON (2024): 107630-107630
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 5 (2024)
crossref(2024)
Mariam Gamaleldin,Nam-Kyung Yu,Jolene Diedrich,Yuanhui Ma, Anne Wienand,Daniel McClatchy,Anders Nykjaer,Sadegh Nabavi,John Robert Yates
biorxiv(2024)
Journal of proteome researchno. 3 (2024): 1129-1129
JOURNAL OF PROTEOME RESEARCHno. 1 (2024): 1-2
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