基本信息
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职业迁徙
个人简介
Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.
研究兴趣
论文共 467 篇作者统计合作学者相似作者
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Nguyen Thi Mai Thu, Hannah Borda, Shawin Vitsupakorn, Kaushik Sreerama Reddy, Navsin Kasmani, Joseph Barwatt,Ilan S. Schwartz,Charles Giamberardino,John R. Perfect,Ngo Thi Hoa,Thuy Le
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The lancet. HIVno. 11 (2023): e750-e754
PLoS pathogensno. 12 (2023): e1011845
Cellno. 13 (2023): 2802-2822.e22
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bioRxiv : the preprint server for biology (2023)
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Dallas J Smith,Jeremy A W Gold,Tom Chiller,Nirma D. Bustamante,Maria Julia Marinissen,G. Rodriquez, Verónica Cortés, Carlos A. Molina,Samantha Williams,Axel A Vazquez Deida,Katrina Byrd,Peter G. Pappas,
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