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个人简介
Research in Dr. McCarrey's lab is centered on the development, differentiation, and epigenetic regulation of mammalian germ cells and stem cells, and on the role of the epigenome as a mediator of environmental effects. Experimental systems include mice, baboons, and other mammals. The lab is interested in 1) the potential for assisted reproductive technologies (e.g. IVF), adverse lifestyles (e.g. poor diet, lack of exercise), or environmental exposures (e.g. disruptive chemicals) to induce disease-causing epimutations in the sperm that are transmitted to a male's offspring, 2) epigenetic specification and maintenance of spermatogonial stem cell fate, 3) maintenance of enhanced genetic integrity in germline and pluripotent cells, 4) regulation of gene expression in germ cells and stem cells, 5) X-chromosome activity or inactivity in germ cells, 6) epigenetic reprogramming during gametogenesis, and 7) developing the baboon as a nonhuman primate model for studies of stem cell-based therapies.
研究兴趣
论文共 145 篇作者统计合作学者相似作者
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024): 1306530-1306530
biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
Methods in molecular biology (Clifton, N.J.) (2023): 71-108
Biology methods & protocolsno. 1 (2023): bpad012-bpad012
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Methods in molecular biology (Clifton, N.J.) (2023): 109-125
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