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职业迁徙
个人简介
Research Description
Viruses are involved in a number of infectious and neoplastic diseases of the respiratory tract in humans. I have been investigating what role the Epstein-Barr virus plays in nasopharyngeal carcinoma (NPC), and in particular two of the viruses proteins (LMP1 and BARF1) which have been implicated in the development of NPC. In particular I have been looking at whether there is “good” or “bad” LMP or BARF1 and how these proteins differ in NPCs from different geographical regions This work involves collaboration with EBV experts from Europe and North America.
In addition I have worked closely with colleagues from the Department of Microbiology in investigating why certain new and emerging viruses such as SARS and H5N1 appear to be so lethal in humans. Is it because they are attacking cells which are not normally attacked by viruses? Is it because they are triggering cells to release too many cytokines, or is it because they are interacting with cell receptors which are not normally expressed in normal conditions? Whatever the results, the main aim of my research is to put a clinical perspective on reducing the damage caused by viruses in the human.
Viruses are involved in a number of infectious and neoplastic diseases of the respiratory tract in humans. I have been investigating what role the Epstein-Barr virus plays in nasopharyngeal carcinoma (NPC), and in particular two of the viruses proteins (LMP1 and BARF1) which have been implicated in the development of NPC. In particular I have been looking at whether there is “good” or “bad” LMP or BARF1 and how these proteins differ in NPCs from different geographical regions This work involves collaboration with EBV experts from Europe and North America.
In addition I have worked closely with colleagues from the Department of Microbiology in investigating why certain new and emerging viruses such as SARS and H5N1 appear to be so lethal in humans. Is it because they are attacking cells which are not normally attacked by viruses? Is it because they are triggering cells to release too many cytokines, or is it because they are interacting with cell receptors which are not normally expressed in normal conditions? Whatever the results, the main aim of my research is to put a clinical perspective on reducing the damage caused by viruses in the human.
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