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Research in the Asara lab focuses on developing approaches to personalized medicine by analyzing cancer cells and tumor samples in order help make appropriate therapeutic decisions with "smart" drugs. The data are generated from a single liquid-liquid extraction from a biological sample for various omics, a process that we term "serial-omics". These integrated datasets provide insight into how kinase signaling communicates with metabolic processes. We are also developing hypothesis directed strategies to understand the fundamental drivers of disease in cancers such as multiple myeloma, lung cancer and prostate cancer by performing protein-protein interaction studies, immunoprecipitation (IP)-tandem mass spectrometry (MS/MS), quantitative phosphoproteomics, 13C/15N metabolic flux analyses with stable isotope labeling and lipidomics profiling. In addition to our internal research, we are involved in many collaborative projects that are coordinated through our state-of-the-art mass spectrometry technologies and services through our mass spectrometry facility. We have demonstrated that these techniques can be applied to any biological source including tumor tissue, cells culture, dried blood spots, urine, hair, etc.
研究兴趣
论文共 436 篇作者统计合作学者相似作者
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Qiuhua Yang,Yongfeng Cai,Qian Ma, Albert Xiong, Peishan Xu, Zhidan Zhang,Jiean Xu,Yaqi Zhou,Zhiping Liu,Dingwei Zhao,John Asara, Wei Li,
Science translational medicineno. 737 (2024): eadk3868-eadk3868
Communications biologyno. 1 (2024): 25-25
Joanne Tejero, Rebecca Hesterberg, Stanislav Drapela, Didem Ilter, Devesh Raizada, Felicia Lazure, Hossein Kashfi, Min Liu,Juan Fernandez-Garcia,Sarah-Maria Fendt,John Asara, John Cleveland,
biorxiv(2024)
Umakant Sahu,Elodie Villa,Colleen R. Reczek,Zibo Zhao, Brendan P. O’Hara, Michael D. Torno, Rohan Mishra, William D. Shannon,John M. Asara,Peng Gao,Ali Shilatifard,Navdeep S. Chandel,
Scienceno. 6690 (2024): 1484-1492
Alexander J. Hu, Wei Li, Calvin Dinh, Yongzhao Zhang, Jamie K. Hu, Stefano G. Daniele,Xiaoli Hou, Zixuan Yang,John M. Asara,Guo-fu Hu, Stephen R. Farmer,Miaofen G. Hu
Nature Communicationsno. 1 (2024): 1-16
Diane Santos,Nathan Raines, Dominic Leone, Juan Amador,Damaris Lopez-Pilarte, Oriana Ramirez,Iris Delgado, Calum Tattersfield,Jessica Leibler,John Asara,Madeleine K. Scammell,Daniel Brooks,
Kidney International Reportsno. 4 (2024): S556-S557
Dávid Deritei,Hiroyuki Inuzuka,Peter J Castaldi,Jeong Hyun Yun,Zhonghui Xu, Wardatul Jannat Anamika,John M Asara,Feng Guo,Xiaobo Zhou,Kimberly Glass,Wenyi Wei,Edwin K Silverman
bioRxiv : the preprint server for biology (2024)
Nathan H. Raines, Dominic A. Leone,Juan Jose Amador,Damaris Lopez-Pilarte, Oriana Ramírez-Rubio,Iris S. Delgado, Lauren J. Francey,Jessica H. Leibler,John M. Asara,Madeleine K. Scammell,Samir M. Parikh,Daniel R. Brooks,
Kidney International Reportsno. 4 (2024): S10-S11
Riadh Lobbardi,Jordan Pinder,Barbara Martinez-Pastor, Marina Theodorou,Jessica S. Blackburn,Brian J. Abraham, Yuka Namiki,Marc Mansour,Nouran S. Abdelfattah,Aleksey Molodtsov,Gabriela Alexe,Debra Toiber,
crossref(2023)
crossref(2023)
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