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个人简介
Dr. VandeBerg established the laboratory opossum as a unique research resource for a broad range of research areas. Laboratory opossums are small marsupials, which are born at the developmental stage of a 6-week human embryo and weigh 60-150g as adults. The embryonic state at birth enables research that is not possible with other laboratory animals. The resource, which has a steady state of 1,200 animals comprising 20 genetic stocks and inbred strains, is used to model human diseases in many of the research initiatives in his laboratory and the laboratories of collaborating scientists from around the world.
A new initiative in his laboratory is the application of CRISPR/Cas9 gene editing to create knockout opossums for the purpose of investigating the function of genes that are of particular interest in the opossum model. This technology was successfully performed with opossums for the first time in 2021. Also in 2021, a collaboration with Dr. Satish Kumar developed the first induced pluripotent stem cell (iPSC) lines from this species, which will be used in stem cell therapy experiments to treat or prevent hypercholesterolemia, non-alcoholic fatty liver disease, and steatohepatitis in a susceptible strain.
A new initiative in his laboratory is the application of CRISPR/Cas9 gene editing to create knockout opossums for the purpose of investigating the function of genes that are of particular interest in the opossum model. This technology was successfully performed with opossums for the first time in 2021. Also in 2021, a collaboration with Dr. Satish Kumar developed the first induced pluripotent stem cell (iPSC) lines from this species, which will be used in stem cell therapy experiments to treat or prevent hypercholesterolemia, non-alcoholic fatty liver disease, and steatohepatitis in a susceptible strain.
研究兴趣
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The UFAW Handbook on the Care and Management of Laboratory and Other Research Animalspp.297-323, (2024)
Wenhe Lin,Jeffrey D Wall,Ge Li, Deborah Newman,Yunqi Yang,Mark Abney,John L VandeBerg,Michael Olivier,Yoav Gilad,Laura A Cox
Cell genomicsno. 3 (2024): 100509-100509
bioRxiv : the preprint server for biology (2023)
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Wenqi Cao,Katharine Horzmann,Bettina Schemera, Myra Petrofski, Trisha Kendall, Jennifer Spooner, Patricia E Rynders,John L VandeBerg,Xu Wang
John Thomas,Juan Garcia, Matthew Terry, Susan Mahaney, Oscar Quintanilla,Dionn Carlo Silva,Marisol Morales,John L. VandeBerg
biorxiv(2023)
Monique Ribeiro de Lima,Ana Cristina C. S. Leandro, Andreia Lamoglia de Souza, Marcio Mantuano Barradas,Eric Henrique Roma,Ana Teresa Gomes Fernandes, Gabrielle Galdino-Silva, Joyce Katiuccia M. Ramos Carvalho,Renato Sergio Marchevsky,Janice M. C. Oliveira Coelho, Eduardo Dantas Casillo Goncalves,John L. Vandeberg,
Vaccinesno. 12 (2023): 1863
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Sobha Puppala, Kimberly D Spradling-Reeves,Jeannie Chan,Shifra Birnbaum,Deborah E Newman,Anthony G Comuzzie,Michael C Mahaney,John L VandeBerg,Michael Olivier,Laura A Cox
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