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个人简介
John Kuriyan’s lab studies the mechanisms, evolution, and structures of the molecular switches that carry out cellular signal transduction. They use biochemical, biophysical, structural and cell biological analyses to elucidate mechanisms, and also study how these mechanisms change with evolution. A major focus of the lab is to understand the allosteric communication that enables proteins to be exquisitely responsive to input signals. We use high-throughput mutational analysis to determine the sensitivity of these mechanisms to perturbations, in order to determine the molecular principles governing regulation and specificity.
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论文共 306 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2024)
Kendra Marcus,Yongjian Huang,Subu Subramanian,Christine L. Gee,Kent Gorday, Sam Ghaffari-Kashani, Xiao Ran Luo,Lisa Zheng,Michael O’Donnell,Sriram Subramaniam,John Kuriyan
Nature Structural & Molecular Biologyno. 3 (2024): 424-435
Dilip Narayanan, Anne Sofie Gry Larsen,Stine Juul Gauger, Ruth Adafia, Rikke Bartschick Hammershøi,Louise Hamborg, Jesper Bruus-Jensen,Nane Griem-Krey,Christine L. Gee,Bente Frølund,Margaret M. Stratton,John Kuriyan,
biorxiv(2024)
Molecular biology and evolution (2024)
Yongjian Huang,Kendra Marcus,Kent Gorday, Sam Ghaffari-Kashani,Christine Gee,Sriram Subramaniam,John Kuriyan
PROTEIN SCIENCEno. 12 (2023)
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PROTEIN SCIENCE (2023)
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