基本信息
浏览量:85
职业迁徙
个人简介
My lab studies the molecular basis of G protein-coupled receptor (GPCR)-mediated signal transduction using small-angle X-ray scattering, X-ray crystallography, and single particle cryo-electron microscopy (cryo-EM). By determining structures of signaling proteins alone and in complex with their various targets, we provide important insights into the molecular basis of signal transduction, explain how diseases result from dysfunctional regulation, and leverage this information to develop new therapeutic approaches. Since 1999, a focus area has been the structure, function, and inhibition of GPCR kinases (GRKs), a family of 7 enzymes in mammals that phosphorylate activated GPCRs and trigger their uncoupling from G proteins and their internalization. Our lab has a longstanding interest in rational drug design targeting GRKs, whose overexpression in disease states such as heart failure, cardiac hypertrophy, and cancer is linked to poor patient outcome. We also investigate the structure and function of other enzymes of central importance to health, including RhoGEFs essential for neutrophil chemotaxis as well as cancer metastasis and a family of acyltransferases that load HDL particles with cholesterol ester or process excess surfactants in alveolar macrophages. We have a strong extramural funding record and are currently supported by three NIH R01 grants.
研究兴趣
论文共 258 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature structural & molecular biologypp.1-10, (2024)
Cancer Researchno. 6_Supplement (2024): 5772-5772
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2024): 115931-115931
Madison F Walker,Jingyi Zhang, William Steiner,Pei-I Ku,Ju-Fen Zhu, Zachary Michaelson,Yu-Chen Yen,Alyssa B Long,Mattie J Casey, Abhishek Poddar,Isaac B Nelson,Corvin D Arveseth,
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
bioRxiv : the preprint server for biology (2023)
bioRxiv : the preprint server for biology (2023)
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
Chun-Liang Chen,Sandeep Ravala,Yu-Chen Yen,Thomas Klose,Ramizah Syahirah,John J. G. Tesmer,Qing Deng
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn