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Research interests
Our group's interests lie in exploring gene-environment interaction in the development of cardiometabolic disease. In particular, we are interested in understanding how diet, the microbiome, and the metabolome interact to drive cardiovascular diseases like atherosclerosis and heart failure. We have assembled a diverse array of tools to enable us to do so: sophisticated metabolomic and lipidomic platforms; murine models of cardiometabolic disease; stable-isotope labelling flux analysis; clinical research clinics incorporating patient samples and imaging, particularly cardiac MRI; and genotyped induced pluripotent stem cell (iPSC) - cardiomyocyte models. We have extensive access to large-scale human databases that have carefully curated outcome phenotypes (e.g. clinical endpoints such as myocardial infarction) and intermediate phenotypes (e.g. omic data) including the Framingham Heart Study and UK Biobank.
We collaborate closely with investigators at the Charles Perkins Centre with overlapping interests and harness their exerptise to significantly advance our research, e.g. Prof David James leading expertise in metabolism, Prof Stephen Simpson's expertise in dietary models, A/Prof Andrew Holmes expertise in the microbiome.
Our group's interests lie in exploring gene-environment interaction in the development of cardiometabolic disease. In particular, we are interested in understanding how diet, the microbiome, and the metabolome interact to drive cardiovascular diseases like atherosclerosis and heart failure. We have assembled a diverse array of tools to enable us to do so: sophisticated metabolomic and lipidomic platforms; murine models of cardiometabolic disease; stable-isotope labelling flux analysis; clinical research clinics incorporating patient samples and imaging, particularly cardiac MRI; and genotyped induced pluripotent stem cell (iPSC) - cardiomyocyte models. We have extensive access to large-scale human databases that have carefully curated outcome phenotypes (e.g. clinical endpoints such as myocardial infarction) and intermediate phenotypes (e.g. omic data) including the Framingham Heart Study and UK Biobank.
We collaborate closely with investigators at the Charles Perkins Centre with overlapping interests and harness their exerptise to significantly advance our research, e.g. Prof David James leading expertise in metabolism, Prof Stephen Simpson's expertise in dietary models, A/Prof Andrew Holmes expertise in the microbiome.
研究兴趣
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