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I am interested in the control of behavior by neuropeptides and the circadian (biological) clock. For several years my lab has investigated the neuroendocrine control of ecdysis, a stereotyped behavior used by insects to shed their old exoskeleton at the end of each molt, and which serves as an excellent model for understanding how neuropeptides trigger complex behavioral routines. We have taken advantage of the powerful genetic and molecular tools available in Drosophila to understand the role of each neuropeptide, and how they act in concert to cause the expression the ecdysial sequence. We also investigate the mechanism by which the circadian clock controls the time of adult ecdysis. For most stages, ecdysis is turned on when the molt is completed. By contrast, ecdysis to the adult (also known as eclosion) is also controlled by the circadian clock, which restricts (“gates”) eclosion to the morning or evening periods, depending on the insect species. Since we know a lot about how the fly’s clock runs and how eclosion behavior (the clock’s output) is regulated, the gating of eclosion by the circadian clock is an excellent system for investigating how this clock imposes a daily rhythmicity to behavioral and physiological outputs.
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Javier Cavieres-Lepe, Emad Amini, Maia Zabel,Dick R Nässel,Ralf Stanewsky,Christian Wegener,John Ewer
Proceedings of the National Academy of Sciences of the United States of Americano. 11 (2024): e2308067121-e2308067121
FRONTIERS IN MOLECULAR NEUROSCIENCE (2021): 666673-666673
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