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职业迁徙
个人简介
There are several major research projects that are currently ongoing in my laboratory. First, one major research area focuses on identifying specific cellular signaling pathways that are disrupted during tumor development and progression. Signaling pathways currently under study include the PI3K/Akt/mTOR pathway and Signal Transducers and Activators of Transcription (Stats), especially Stats1,3 and 5. Another important research area involves studies aimed at identifying the target cells (i.e., stem/progenitor cells) for tumor development. Using a novel gene knockout strategy we have recently shown that keratinocyte stem cells located in the bulge region of hair follicles are the major targets for the initiation of skin (epithelial) tumors in mice. Further study of these cells and their role in tumor development will lead to novel strategies and targets for both prevention and treatment of epithelial cancers. Another important area of research involves identifying genes that confer susceptibility to environmentally-induced cancer. These studies have used genetic crosses between sensitive and resistant mice to map genes involved in the promotion of skin tumors in mice. Using this approach we recently mapped and identified a gene (Gsta4) on Chr 9 that is involved in susceptibility to skin tumor development in mice. We also found that polymorphisms in this gene are risk alleles for human non-melanoma skin cancer (both basal cell carcinoma and squamous cell carcinoma). We are currently examining this gene in other human cancers and also working to identify genes in other regions of mouse chromosomes identified from our initial screen that harbor susceptibility loci. These studies also incorporate the novel approach of using “genetical genomics” to help identify novel genes, pathways and networks involved in cancer susceptibility.
研究兴趣
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The Journal of urologyno. 4 (2024): 552-562
Rachel Clark,Achinto Saha, Chelsea A. Friedman, Ruggiero Gorgoglione,Stefano Tiziani,John DiGiovanni
Cancer Researchno. 6_Supplement (2024): 7300-7300
biorxiv(2024)
Michael A. Liss, Furkan Durson,G. Lavender Hackman, Mohamed I. Gadallah,Achinto Saha, Chelsea A. Friedman,Atul S. Rathore, Preeti Chandra,James R. White,Stefano Tiziani,John DiGiovanni
Journal of Traditional and Complementary Medicine (2024)
FEBS LETTERSno. 3 (2024): 338-346
CANCER LETTERS (2024)
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Cancer Letters (2024): 216552
Chelsea A. Friedman,Achinto Saha,G. Lavender Hackman,Xiyuan Lu,Alessia Lodi,Stefano Tiziani,John DiGiovanni
MOLECULAR CARCINOGENESISno. 4 (2024): 589-600
Zanobia Syed,Satish B. Cheepala, Jennifer N. Gill, Jennica Stein,Cherie Ann Nathan,John DiGiovanni, Vinita Batra, Patrick Adegboyega, Heather E. Kleiner,John L. Clifford
crossref(2023)
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