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Our groups two main research interests are the immunobiology of cytokines and the control of parasitic infections with a focus on leishmaniasis, We produced recombinant migration inhibitory factor (rMIF), the first lymphokine discovered in the 1960s, and are determining the biological role of the 12kD recombinant cytokine. RMIF has marked effects on the physiology of macrophages, a cell important in the afferent limb of the immune response and in mechanisms of inflammation. Studies by others have shown the presence of MIF-MRNA in numerous cell types suggesting it has other functions as well. They have shown that MIF is important in the pathogenesis of endotoxic shock, inhibits the antiinflammatory effects of corticosteroids, plays a role in the development of the eye, and enhances the secretion of insulin.
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Ingrid He,Michael Luu, Veronica Placencio,Varun Roy,John David,Michelle Guan,Richard Tuli,Andrew Hendifar
PANCREASno. 3 (2019): 437-438
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Yi Lao,John David,Arman Torosian, Veronica Placencio,Yalin Wang,Andrew Hendifar,Wensha Yang,Richard Tuli
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