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The laboratory of John D. Fryer, Ph.D., studies the pathogenesis of Alzheimer's disease, focusing on molecular mechanisms of known genetic risk factors. Some of these genetic risk factors are known to be involved in immune system function, likely mediated by the resident immune cells of the brain (microglia).
Interestingly, the same populations at risk of Alzheimer's disease are also at high risk of sepsis, a devastating condition that can lead to disability and long-term cognitive dysfunction. Dr. Fryer seeks to understand whether these inflammatory pathways converge on individuals to initiate a spiraling cognitive decline.
His research team pursues these research avenues with biochemical and molecular techniques, using a variety of mouse genetic models and in vitro systems.
Focus areas
The role of CLU and TREM2 in Alzheimer's disease pathogenesis. The CLU and TREM2 genes are important genetic risk factors for the development of Alzheimer's disease. Dr. Fryer's lab uses mouse models of Alzheimer's disease to determine how these genes are involved in the development of amyloid formation in brain parenchyma as well as cerebral amyloid angiopathy. The lab also studies the role of these genes in the formation of tau pathology.
Consequences of neuroinflammation following sepsis. Older adults who survive sepsis are at high risk of developing long-term cognitive impairment. Dr. Fryer's team seeks to understand whether specific molecules play a prominent role in this process, and could therefore be targeted for therapy to prevent post-sepsis cognitive decline.
The role of the gut microbiome in mental health. The microbes in the gut and their collective genomes (the microbiome) have an increasingly recognized role in human health and disease. Dr. Fryer's team found that a high-fat diet and exercise both dramatically alter the levels of these microbes, with some specifically associationed with levels of anxiety and cognition. The lab is now pursuing investigations of how the gut microbiome can be manipulated to alter mood and cognition in both mouse models and human populations.
AREAS OF RESEARCH
Alzheimer's Disease Research Center
Discovery and Translation Labs: Brain Research
Neuroscience Research
Center for Immunology and Immune Therapies
Discovery and Translation Labs
Interestingly, the same populations at risk of Alzheimer's disease are also at high risk of sepsis, a devastating condition that can lead to disability and long-term cognitive dysfunction. Dr. Fryer seeks to understand whether these inflammatory pathways converge on individuals to initiate a spiraling cognitive decline.
His research team pursues these research avenues with biochemical and molecular techniques, using a variety of mouse genetic models and in vitro systems.
Focus areas
The role of CLU and TREM2 in Alzheimer's disease pathogenesis. The CLU and TREM2 genes are important genetic risk factors for the development of Alzheimer's disease. Dr. Fryer's lab uses mouse models of Alzheimer's disease to determine how these genes are involved in the development of amyloid formation in brain parenchyma as well as cerebral amyloid angiopathy. The lab also studies the role of these genes in the formation of tau pathology.
Consequences of neuroinflammation following sepsis. Older adults who survive sepsis are at high risk of developing long-term cognitive impairment. Dr. Fryer's team seeks to understand whether specific molecules play a prominent role in this process, and could therefore be targeted for therapy to prevent post-sepsis cognitive decline.
The role of the gut microbiome in mental health. The microbes in the gut and their collective genomes (the microbiome) have an increasingly recognized role in human health and disease. Dr. Fryer's team found that a high-fat diet and exercise both dramatically alter the levels of these microbes, with some specifically associationed with levels of anxiety and cognition. The lab is now pursuing investigations of how the gut microbiome can be manipulated to alter mood and cognition in both mouse models and human populations.
AREAS OF RESEARCH
Alzheimer's Disease Research Center
Discovery and Translation Labs: Brain Research
Neuroscience Research
Center for Immunology and Immune Therapies
Discovery and Translation Labs
研究兴趣
论文共 143 篇作者统计合作学者相似作者
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Kimberly C. Olney,Camila de Ávila, Kennedi T. Todd, Lauren E. Tallant, J. Hudson Barnett, Katelin A. Gibson, Piyush Hota, Adithya Shyamala Pandiane, Pinar Cay Durgun,Michael Serhan, Ran Wang,Mary Laura Lind,
Journal of Neuroinflammationno. 1 (2024): 1-20
Mika P. Cadiz, Katelin A. Gibson, Kennedi T. Todd, David G. Nascari, Nashali Massa,Meredith T. Lilley,Kimberly C. Olney,Md Mamun Al-Amin,Hong Jiang,David M. Holtzman,John D. Fryer
JOURNAL OF EXPERIMENTAL MEDICINEno. 2 (2024)
Nature Immunologyno. 11 (2023): 1854-1866
Bernardo Aguzzoli Heberle,J Anthony Brandon,Madeline L Page, Kayla A Nations, Ketsile I Dikobe, Brendan J White, Lacey A Gordon,Grant A Fox,Mark E Wadsworth,Patricia H Doyle, Brittney A Williams, Edward J Fox,
bioRxiv : the preprint server for biology (2023)
MOLECULAR NEURODEGENERATIONno. 1 (2023)
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Biomedicinesno. 10 (2023): 2863-2863
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