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个人简介
John Condeelis' research interests are in optical physics, cell biology and biophysics, cancer biology and mouse models of cancer. He and his collaborators developed the multiphoton imaging technology and animal models used to identify invasion and intravasation micro-environments in mammary tumors. Integration of intravital multiphoton imaging with computational /systems analysis of living breast tumors identified the dominant tumor cell phenotypes contributing to invasion and dissemination during metastasis. This led to the discovery and verification of the paracrine interaction between tumor cells and macrophages in vivo, the role of macrophages in the migration of tumor cells during HGF-dependent tumor cell streaming to blood vessels and the mechanism of tumor cell dissemination from primary tumors via TMEM (Tumor MicroEnvironment of Metastasis) to distant metastatic sites. Based on these results, cell collection techniques, including the in vivo invasion assay were developed for the collection of migrating and disseminating macrophages and tumor cells. This led to the discovery of the mouse and human invasion signatures, and the TMEM, MenaCalc and MenaINV markers for assessing risk of metastasis and prediction of response in breast cancer patients to both chemotherapy, and receptor tyrosine kinase and tyrosine kinase inhibitors used to suppress metastasis.
John Condeelis has devised optical microscopes for uncaging, biosensor detection and multiphoton imaging for these studies and has used novel caged-enzymes and biosensors to test, in vivo, the predictions of the invasion signatures regarding the mechanisms of tumor cell dissemination and metastasis. He is one of the founding co-directors of the Integrated Imaging Program dedicated to the integration and validation of clinical imaging platforms, including digital pathology, with high resolution optical imaging in the Gruss Lipper Biophotonics Center. He has authored more than 300 scientific papers on various aspects of his research.
研究兴趣
论文共 496 篇作者统计合作学者相似作者
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Chinmay R Surve,Camille L Duran,Xianjun Ye,Xiaoming Chen,Yu Lin,Allison S Harney,Yarong Wang,Ved P Sharma,E. Richard Stanley, Dianne Cox, John C McAuliffe,David Entenberg,
biorxiv(2024)
Christopher C. Mader,Matthew Oser,Marco A. O. Magalhaes,Jose Javier Bravo-Cordero,John Condeelis,Anthony J. Koleske,Hava Gil-Henn
crossref(2023)
Sumanta Goswami,Erik Sahai, Jeffrey B. Wyckoff,Michael Cammer,Dianne Cox,Fiona J. Pixley,E. Richard Stanley, Jeffrey E. Segall,John S. Condeelis
crossref(2023)
Chengsen Xue,Jeffrey Wyckoff,Fubo Liang, Mazen Sidani, Stefania Violini, Kun-Lin Tsai,Zhong-Yin Zhang,Erik Sahai,John Condeelis, Jeffrey E. Segall
crossref(2023)
Weigang Wang, Sumanta Goswami,Kyle Lapidus, Amber L. Wells, Jeffrey B. Wyckoff,Erik Sahai,Robert H. Singer, Jeffrey E. Segall,John S. Condeelis
crossref(2023)
Jeffrey B. Wyckoff,Yarong Wang, Elaine Y. Lin,Jiu-feng Li, Sumanta Goswami,E. Richard Stanley, Jeffrey E. Segall, Jeffrey W. Pollard,John Condeelis
crossref(2023)
Dimitra P. Anastasiadou, Luis R. Sanchez,Camille L. Duran, Joseph Burt,Xiaoming Chen, Yu Ting Lin,Robert J. Eddy,Allison S. Harney,David Entenberg,John S. Condeelis,Maja H. Oktay,George S. Karagiannis
Cancer Researchno. 7_Supplement (2023): 60-60
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Jeffrey B. Wyckoff,Yarong Wang,Elaine Y. Lin,Jiu-feng Li,Sumanta Goswami,E. Richard Stanley, Jeffrey E. Segall, Jeffrey W. Pollard,John Condeelis
crossref(2023)
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