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Central to defense against pathogenic microorganisms is the macrophage's ability to internalize fluids and particles by endocytosis, which includes the processes of phagocytosis, receptor-mediated endocytosis and macropinocytosis. This lab uses quantitative cell biological and microscopic methods to study endocytosis in macrophages. The principle goals are to delineate the mechanisms and regulation of phagocytosis and macropinocytosis, and to characterize the intravacuolar environment in the presence of pathogenic bacteria. These goals are important for understanding macrophage biology and for elucidating how microbes cause disease.
Central to defense against pathogenic microorganisms is the macrophage's ability to internalize fluids and particles by endocytosis, which includes the processes of phagocytosis, receptor-mediated endocytosis and macropinocytosis. This lab uses quantitative cell biological and microscopic methods to study endocytosis in macrophages. The principle goals are to delineate the mechanisms and regulation of phagocytosis and macropinocytosis, and to characterize the intravacuolar environment in the presence of pathogenic bacteria. These goals are important for understanding macrophage biology and for elucidating how microbes cause disease.
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Shayne E. Quinn, Lu Huang,Jason G. Kerkvliet,Joel A. Swanson,Steve Smith,Adam D. Hoppe,Robert B. Anderson,Natalie W. Thiex,Brandon L. Scott
Nature Communicationsno. 1 (2021): 7266-7266
Nature Communicationsno. 1 (2021): 1-12
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