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Dr. Kurtzberg conducts both clinical and laboratory-based translational research efforts, all involving various aspects of normal and malignant hematopoiesis. In the laboratory, her early work focused on studies determining the mechanisms that regulate the choice between the various pathways of differentiation available to the pluripotent hematopoietic stem cell. Her laboratory established a CD7+ cell line, DU.528, capable of multilineage differentiation as well as self-renewal, and subsequently described the aggressive leukemic syndrome of CD7+ALL and demonstrated that a normal counterpart of the CD7+, TN malignant cell can be isolated from postnatal human thymus, bone marrow, umbilical cord blood and G-CSF mobilized peripheral blood progenitor cells. The leukemic CD7+ cell has been established in model systems nude and SCID mice where direct IL2-cytotoxicity has been demonstrated. The mechanism of IL2-induced cytotoxicity is currently a major focus of work in the laboratory.
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论文共 168 篇作者统计合作学者相似作者
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Ken Mautner,Michael Gottschalk,Scott D. Boden, Alison Akard,Won C. Bae, Lora Black, Blake Boggess,Paramita Chatterjee,Christine B. Chung,Kirk A. Easley,Greg Gibson, Josh Hackel,
Nature Medicineno. 3 (2024): 905-905
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Stem Cells Translational Medicineno. Supplement_1 (2023): S31-S31
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medRxiv : the preprint server for health sciences (2023)
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Stem Cells Translational Medicineno. Supplement_1 (2023): S32-S32
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