Joanne Konkel
BBSRC David Phillips Fellow
Division of Immunology
Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester;Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester;Manchester Collaborative Centre for Inflammation Research, The University of Manchester
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个人简介
Our research
Mucosal barrier sites pose a particular challenge for the immune system. These barriers, such as the Gastrointestinal (GI) tract and Oral mucosa, are sites of frequent pathogen invasion but also home to diverse commensal microbial communities.
As such, the immune system must be carefully tailored to the tissue microenvironment to limit aberrant responses to commensals while allowing for rapid development of an immune response to protect against the invader. Failure to achieve this has pathological consequences such as the development of inflammatory bowel diseases (Gastrointestinal tract) and Periodontitis (Oral mucosa).
Consequently, specialised immune cell networks have developed to help mediate effective immunological control of these dynamic barrier environments.
Our research programme focuses on understanding how the immune system is tailored to these unique barrier surfaces and how these networks evolve with age. Indeed, to mediate immune homeostasis at the barrier sites of GI tract and oral mucosa, conventional and unconventional immune cells are present which are conditioned by the microenvironment.
Our recent work has examined the development and differentiation of T cells at barrier sites, understanding how barrier-specific cues, in particular the cytokine TGFβ, eeducates T cells about their environment and drives them to adopt certain phenotypic and functional characteristics.
Mucosal barrier sites pose a particular challenge for the immune system. These barriers, such as the Gastrointestinal (GI) tract and Oral mucosa, are sites of frequent pathogen invasion but also home to diverse commensal microbial communities.
As such, the immune system must be carefully tailored to the tissue microenvironment to limit aberrant responses to commensals while allowing for rapid development of an immune response to protect against the invader. Failure to achieve this has pathological consequences such as the development of inflammatory bowel diseases (Gastrointestinal tract) and Periodontitis (Oral mucosa).
Consequently, specialised immune cell networks have developed to help mediate effective immunological control of these dynamic barrier environments.
Our research programme focuses on understanding how the immune system is tailored to these unique barrier surfaces and how these networks evolve with age. Indeed, to mediate immune homeostasis at the barrier sites of GI tract and oral mucosa, conventional and unconventional immune cells are present which are conditioned by the microenvironment.
Our recent work has examined the development and differentiation of T cells at barrier sites, understanding how barrier-specific cues, in particular the cytokine TGFβ, eeducates T cells about their environment and drives them to adopt certain phenotypic and functional characteristics.
研究兴趣
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Peter C Cook,Sheila L Brown,Emma Louise Houlder, Syed Baker,Freya R Svedberg,Gareth Howell,Margherita Bertuzzi, Louis Boon,Joanne E Konkel, Judith E Allen,Andrew S MacDonald
biorxiv(2024)
Christine Chew,Oliver J. Brand, Tomohiko Yamamura,Craig Lawless, Mychel Raony Paiva Teixeira Morais,Leo Zeef, I-Hsuan Lin,Gareth Howell, Sylvia Lui,Franziska Lausecker,Christopher Jagger,Tovah N. Shaw,
Discovery immunologyno. 1 (2023): kyad005-kyad005
EUROPEAN RESPIRATORY JOURNAL (2023)
Frontiers in Microbiomes (2023)
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The European respiratory journalno. 5 (2023): 2202226-2202226
Ian Prise, V. Jayaraman,Verena Kästele,Rufus H Daw,Kelly Wemyss,Hayley Bridgeman, Sabrina Tamburrano, Sheila Patrick, Christine Chew,Liesbet Martens,Charlotte Scott,Martin Guilliams,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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The Journal of investigative dermatologyno. 9 (2022): 2446-2454.e3
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