基本信息
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个人简介
Research Interests
We design algorithms to understand gene regulation and DNA damage and repair, to characterize disruptions of these processes in disease, and to discover therapeutic targets.
Computer Science
Algorithms
Machine learning
Data mining
Special interests:
combinatorial algorithms
n-way clustering
time course analysis
domain-driven data integration
Molecular biology
Transcriptional regulation
Epigenetic regulation
DNA damage and repair
Examples of data we analyse:
Gene expression
TF-DNA binding
Epigenomics
Gene disruption and editing readouts (CRISPR + sequencing)
Gene essentiality
Mutation patterns and signatures
Biomedicine (cancer)
Focus on disruption of relationships and pathways rather than single functional elements (i.e. genes).
Major regulation of disrupted pathways.
Mechanisms involved in drug resistance.
Gene essentiality and synthetic lethality relationships.
DNA damage and repair.
研究兴趣
论文共 75 篇作者统计合作学者相似作者
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引用量
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期刊级别
合作者
合作机构
International journal of molecular sciencesno. 6 (2023): 6010-6010
Molecules (Basel, Switzerland)no. 5 (2023): 2030-2030
BIOINFORMATICSno. 1 (2022)
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