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Jo Anne Stratton’s research interests are inspired by the complex and context-dependent interactions of immune cells within the nervous system which function to modulate repair and plasticity, but can also underlie pathologies such as demyelination and axonal degeneration leading to cognitive impairment and sensory/motor deficits. Her research platform spans basic in vitro cell culture interrogation of cellular interactions, to transgenic animal models which recapitulate responses to different injuries and diseases, to human cellular and histological analyses.
In particular, Stratton studies the function of one largely understudied, specialized glia cell in the central nervous system: the ependymal cell, to explore its role in multiple sclerosis (MS) and neurodegeneration. Ependymal cells are multiciliated cells that form the brain’s ventricular epithelium and provide a niche for neural stem cells (NSCs) in the ventricular subventricular zone (V-SVZ) but have been difficult to study due to a lack of transgenic labelling techniques that can effectively distinguish ependymal cells from neighboring NSCs. This problem also makes it difficult to study their direct interactions with and response to the immune system under homeostatic and injured or diseased states.A key component of the Stratton Lab is to develop and implement state-of-the-art techniques for assessing the role of ependymal cells in disease and inflammation.
Dr Stratton is also involved with creating awareness about disability and disease, and how groundbreaking advancements in research technology is quickly shaping our future.
In particular, Stratton studies the function of one largely understudied, specialized glia cell in the central nervous system: the ependymal cell, to explore its role in multiple sclerosis (MS) and neurodegeneration. Ependymal cells are multiciliated cells that form the brain’s ventricular epithelium and provide a niche for neural stem cells (NSCs) in the ventricular subventricular zone (V-SVZ) but have been difficult to study due to a lack of transgenic labelling techniques that can effectively distinguish ependymal cells from neighboring NSCs. This problem also makes it difficult to study their direct interactions with and response to the immune system under homeostatic and injured or diseased states.A key component of the Stratton Lab is to develop and implement state-of-the-art techniques for assessing the role of ependymal cells in disease and inflammation.
Dr Stratton is also involved with creating awareness about disability and disease, and how groundbreaking advancements in research technology is quickly shaping our future.
研究兴趣
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Abdulshakour Mohammadnia,Qiao-Ling Cui,Chao Weng,Moein Yaqubi, Milton G F Fernandes, Jeffery A Hall,Roy Dudley,Myriam Srour,Timothy E Kennedy,Jo Anne Stratton,Jack P Antel
Brain communicationsno. 2 (2024): fcae109-fcae109
Sienna S Drake,Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale,Elia Afanasiev,Jo Anne STRATTON,Alyson Fournier
biorxiv(2024)
Alexandra Kazanova, Jacqueline Sung, Nathalia Luisa Oliveira,Christina Gavino, Hicham Bessaiah, Jessica Pei, Lindsay Burns, Willemein Miller, Morgane Brouillard-Galipeau, Lei Zhu, Lucia Marguerite Guerra, Moustafa Nouh Elemeery,
biorxiv(2024)
Helene Jamann,Haritha L. Desu,Qiao-Ling Cui, Alexandre Halaweh,Olivier Tastet, Wendy Klement,Stephanie Zandee,Florian Pernin,Victoria H. Mamane,Oumarou Ouedraogo,Audrey Daigneault, Hadjara Sidibe,
Marie-France Dorion, Diana Casas,Irina Shlaifer,Moein Yaqubi, Peter Fleming, Nathan Karpilovsky,Carol X.-Q. Chen,Michael Nicouleau,Valerio E. C. Piscopo,Emma J. MacDougall, Aeshah Alluli,Taylor M. Goldsmith,
Molecular Neurodegenerationno. 1 (2024): 1-26
Sherilyn Junelle Recinto, Shobina Premachandran,Sriparna Mukherjee, Alexis Allot,Adam Macdonald,Moein Yaqubi,Samantha Gruenheid,Louis-Eric Trudeau,Jo Anne Stratton
EUROPEAN JOURNAL OF NEUROSCIENCE (2024)
Armin Bayati,Riham Ayoubi,Cornelia E. Zorca, Adriana Aguila,Chanshuai Han,Emily Banks, Emmanuelle Nguyen-Renou,Wen Luo,Irina Shlaifer,Esther Del Cid-Pellitero,Moein Yaqubi,Edward A. Fon,
biorxiv(2023)
Elena Barusolo,Lauren Griffiths,Lewis Watkins, Mahshad Karimian,Antonella Mensi,Stefano Magon, Marina Mastantuono, Gian Marco Berti, Diana Bazan,Stefania Rossi,Simon Hametner,Jo Anne Stratton,
MULTIPLE SCLEROSIS JOURNAL (2023): 499-500
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