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The Rossi Lab has as its primary focus studies on the functions and therapeutic applications of small RNAs. Within the past two decades there has been an explosion of new findings about roles that small RNAs play in biological processes. Ribozymes are RNA molecules with enzymatic activities. There are many different types of ribozymes in nature but our lab has focused upon the hammerhead motif which is found as part of the self-cleaving domain of small plant viruses. We have exploited these ribozymes for both basic studies of RNA catalysis and for therapeutic applications. Ribozymes developed in our research program have been developed to target HIV and these have been inserted into human blood progenitor cells via a retroviral vector as part of a gene therapy program for the treatment of HIV infection. To date 10 HIV positive patients have been treated with ribozymes developed in the lab. Efforts to improve catalytic efficiency and co-localization of ribozymes with their targets in mammalian cells are still an ongoing effort in the lab.
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论文共 613 篇作者统计合作学者相似作者
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Molecular Therapy - Nucleic Acidsno. 2 (2024): 102153-102153
Pål Sætrom,Jacob Biesinger, Sierra M. Li,David Smith,Laurent F. Thomas,Karim Majzoub, Guillermo E. Rivas,Jessica Alluin,John J. Rossi, Theodore G. Krontiris,Jeffrey Weitzel,Mary B. Daly,
crossref(2023)
Nagy Habib,Vikash Reebye, Konstantinos Vanezis, Luke Haslett, Konstantina Skourti-Stathaki,Brid Ryan,John J. Rossi,Min-Sun Song,Michael J. Przybilla,Laura Furness,Chester B. Whitley,Robert Habib,
Molecular Genetics and Metabolismno. 2 (2023): 107134-107134
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Michael J. Przybilla,Vikash Reebye, Konstantinos Vanezis, Konstantina Skourti Stathaki,John J. Rossi,Min-Sun Song, Laura Furness,Simon Jones,Nagy A. Habib,Chester B. Whitley
MOLECULAR THERAPYno. 4 (2023): 189-190
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Molecular Therapy - Nucleic Acids (2023): 730-730
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Pål Sætrom,Jacob Biesinger, Sierra M. Li,David Smith,Laurent F. Thomas,Karim Majzoub,Guillermo E. Rivas,Jessica Alluin,John J. Rossi, Theodore G. Krontiris,Jeffrey Weitzel,Mary B. Daly,
crossref(2023)
CELL REPORTS METHODSno. 12 (2023): 100667-100667
Minsun Song,Haitang Li,Jessica Alluin, Trishabelle Manzano, Cynthia Rojero,Nicolette Pollock, Kevin Holm,Nagy A. Habib,John J. Rossi
MOLECULAR THERAPYno. 4 (2023): 43-44
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