基本信息
浏览量:0
职业迁徙
个人简介
Alternative splicing is a posttranscriptional mechanism that explains how individual genes can produce more than one transcript due to the inclusion or exclusion of specific regions originating multiple protein isoforms with diverse features. More than 90% of human genes undergo alternative splicing. This high prevalence raises the question of how developmental stage- and tissue-specific splicing influence protein function and how this regulation occurs
In our lab we are interested on how alternative splicing regulates the expression of trafficking and membrane dynamics proteins in normal development and diseases. A second angle of the lab is how alternative splicing impacts on the functions of these proteins and thus in internal cell architecture and physiology. We are initially focused on striated muscles (heart and skeletal muscle) because we found that trafficking and membrane dynamics genes are regulated by splicing specifically in these tissues and some of them also in brain. Misregulation of membrane trafficking proteins is one hallmark of muscle and brain disorders. In particular, striated muscle cells have contractility primordial functions that require a very precise formation and maintenance of internal architecture through membrane invagination and trafficking processes. Receptors and ion channels need to be correctly transported to these locations to exert their key functions. We are studying the crosstalk between alternative splicing and membrane trafficking and its contribution to the maturation and maintenance of the myocyte exquisite architecture and functions.
研究兴趣
论文共 68 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Hannah J. Wiedner,R. Eric Blue, Matheus Sadovsky,C. Allie Mills,Xander H.T. Wehrens,Laura E. Herring,Jimena Giudice
iScienceno. 11 (2023): 108258-108258
CIRCULATION RESEARCHno. Suppl_1 (2023)
Droplets of Lifepp.337-373, (2023)
引用0浏览0引用
0
0
The FEBS Journalno. 21 (2022): 6799-6816
引用0浏览0引用
0
0
The FEBS journalno. 21 (2022): 6799-6816
Gabrielle M Gentile, Jennifer R Gamarra,Nichlas M Engels,R Eric Blue,Isabel Hoerr,Hannah J Wiedner,Emma R Hinkle,Jessica L Cote, Elise Leverence,Christine A Mills,Laura E Herring,Xianming Tan,
Nature Structural & Molecular Biologyno. 11 (2022): 1145-1145
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn