基本信息
浏览量:53
职业迁徙
个人简介
His research now focuses on unravelling the function of noncoding human genome.
Research Interests
Due to high mutation burden in regulatory elements, affected cells develop aberrant gene transcription compared with surrounding normal cells that could device them with growth advantage. Some noncoding RNA transcripts have been used as clinical diagnostic markers for some diseases whereas the molecular mechanism of their relevance largely elusive. Our research goal is to unveil molecular mechanism of how transcriptional aberration affects cellular function and human health issues, using high throughput, state-of-the-art tools. My current interest focuses on developing genomic tools to:
Dissect of lncRNA function and mechanism in disease
Identify of genetic variations that contribute to disease pathogenesis
Study protein-chromatin binding with extremely low number of cells and apply it to study cell heterogeneity
Research Interests
Due to high mutation burden in regulatory elements, affected cells develop aberrant gene transcription compared with surrounding normal cells that could device them with growth advantage. Some noncoding RNA transcripts have been used as clinical diagnostic markers for some diseases whereas the molecular mechanism of their relevance largely elusive. Our research goal is to unveil molecular mechanism of how transcriptional aberration affects cellular function and human health issues, using high throughput, state-of-the-art tools. My current interest focuses on developing genomic tools to:
Dissect of lncRNA function and mechanism in disease
Identify of genetic variations that contribute to disease pathogenesis
Study protein-chromatin binding with extremely low number of cells and apply it to study cell heterogeneity
研究兴趣
论文共 45 篇作者统计合作学者相似作者
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Ling Lü,Chenxi Zheng, Ning Zhao,Ting Zhu, Chen Hu,Nan Zhang, Ji Chen,Kaichao Zhang,Sha Zhang,Jie‐Xi Liu,Kai Zhang,Huan Jing,
Advanced Healthcare Materialsno. 20 (2023)
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ONCOGENEno. 21 (2022): 2945-2957
PAOLA BENAGLIO,HAN ZHU,MEI-LIN OKINO,JIAN YAN,RUTH ELGAMAL,NAOKI NARIAI,ELISHA BEEBE,KATHA KORGAONKAR,YUNJIANG QIU,MARGARET DONOVAN,JOSHUA CHIOU, JACKLYN M. NEWSOME ASHMUS,
Shaorong Fan,Wenju Sun,Ligang Fan,Nan Wu,Wei Sun, Haiqian Ma,Siyuan Chen, Zitong Li,Yu Li,Jilin Zhang,Jian Yan
crossref(2021)
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