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The Gallop Group studies how the actin cytoskeleton is assembled in different ways. The cell membrane is an important site of control of actin rearrangements because it is the boundary between the outside and inside of the cell and is responsible for initiating communication between and within cells, which is called signalling. We have developed cell-free systems using phospholipid bilayers and frog egg extracts that allow us to find out how signalling lipids in the cell membrane precisely control the molecular events of actin assembly. We combine these cell-free systems with the use of fruit flies, frog embryos and cultured human cells to test and generate hypotheses about the molecular events underlying actin regulation during development and in disease.
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论文共 36 篇作者统计合作学者相似作者
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Thomas C A Blake,Helen M Fox,Vasja Urbančič, Roshan Ravishankar, Adam Wolowczyk,Edward S Allgeyer,Julia Mason, Gaudenz Danuser,Jennifer L Gallop
Journal of cell scienceno. 6 (2024)
Annual review of cell and developmental biologyno. 1 (2023): 307-329
biorxiv(2019)
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