基本信息
浏览量:64
职业迁徙
个人简介
Research Interests
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
研究兴趣
论文共 381 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Ze Tian,Chunhua Shi, Guojun Yang, Jason K. Allen, Qing Shi, Amin AL-Shami, Jill Wardell Olson,Melinda G. Smith,Qing Chang,Jasbir Kaur,Junping You,Timothy E. Lofton,
LEUKEMIAno. 1 (2024): 226-226
Jeffrey Molldrem, Hong He, Rolando Vedia,Sijie Lu, Qiaochuan Li,Kathryn Cox, Lisa St John,Anna Sergeeva,Karen Clise-Dwyer,Gheath Alatrash,Elizabeth Shpall,Qing Ma
Research square (2024)
crossref(2023)
Jason K Allen,Michelle A Gonzalez,Jasbir Kaur,Melinda Smith,Junping You,Guojun Yang,Dongxing Zha, Ze Tian, Amin Al-Shami,Chunhua Shi,Jeffrey J Molldrem,Tim Heffernan
biorxiv(2023)
crossref(2023)
Robert Jenq,Eiko Hayase,Tomo Hayase, Akash Mukherjee, Stuart Stinson,Mohamed Jamal, Miriam Ortega,Christopher Sanchez,Saira Ahmed,Jennifer Karmouch,Chia-Chi Chang,Ivonne Flores,
Research Square (Research Square) (2023)
crossref(2023)
Mao Zhang,Pariya Sukhumalchandra, Atim A. Enyenihi,Lisa S. St. John,Sally A. Hunsucker,Elizabeth A. Mittendorf,Anna Sergeeva,Kathryn Ruisaard,Zein Al-Atrache, Patricia A. Ropp, Haroon Jakher, Tania Rodriguez-Cruz,
crossref(2023)
Cancer Researchno. 8_Supplement (2023): CT101-CT101
Clinical Cancer Research (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn