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Friedman studies the molecular and neural mechanisms that regulate food intake and body weight. Genetic studies in mice led to the identification of leptin, a hormone made by fat tissue that plays a key role in controlling appetite and weight. His current work explores the mechanisms by which leptin regulates energy balance and seeks to identify other key regulators of body weight.
Leptin maintains body weight within a relatively narrow range. Increased fat mass increases leptin levels, which in turn reduces body weight; decreased fat mass decreases leptin levels and increases body weight. Defects in the leptin gene are associated with severe obesity, and leptin treatment normalizes weight in these patients. Leptin also improves the severe diabetes and abnormal lipids in patients with lipodystrophy, and is now an FDA-approved treatment for this condition.
Leptin maintains body weight within a relatively narrow range. Increased fat mass increases leptin levels, which in turn reduces body weight; decreased fat mass decreases leptin levels and increases body weight. Defects in the leptin gene are associated with severe obesity, and leptin treatment normalizes weight in these patients. Leptin also improves the severe diabetes and abnormal lipids in patients with lipodystrophy, and is now an FDA-approved treatment for this condition.
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biorxiv(2024)
Han L. Tan,Luping Yin, Yuqi Tan, Jessica Ivanov, Kaja Plucinska,Anoj Ilanges,Brian R Herb,Putianqi Wang, Christin Kosse,Paul Cohen,Dayu Lin,Jeffrey M Friedman
biorxiv(2024)
bioRxiv : the preprint server for biology (2023)
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bioRxiv : the preprint server for biology (2023)
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SCIENCE TRANSLATIONAL MEDICINEno. 723 (2023): eadh4453-eadh4453
Cell Metabolismno. 3 (2023): 429-+
Marc Schneeberger, Nicola L. Brice,Kyle Pellegrino,Luca Parolari,Jordan T. Shaked, Keith J. Page,François Marchildon,Douglas W. Barrows,Thomas S. Carroll,Thomas Topilko, Victoria M. Mulligan, Robert Newman,
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